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2026-06-03
08:00
2026 ASCO | 科倫博泰創新B7-H3 ADC SKB500首次人體研究數據公布

成都2026年6月3日 /美通社/ -- 2026年6月3日,四川科倫博泰生物醫藥股份有限公司(「科倫博泰」或「公司」,6990.HK)宣布,在美國芝加哥舉行的2026年美國臨床腫瘤學會(ASCO)年會上,吉林省腫瘤醫院劉海峰教授以快速口頭報告的形式公布了創新B7-H3 ADC SKB500治療晚期實體瘤的首次人體研究結果(摘要編號#3011 |分子靶向藥物與腫瘤生物學)。

SKB500采用了高親和力、高親水性及內吞作用更強的抗體,並在抗體恆定區進行了沉默Fc效應功能的工程改造。此外,其抗體通過可裂解的親水性AAA連接子與具有中等毒性的載荷連接,藥物抗體比(DAR)約為8。

研究分為劑量遞增、劑量擴展及適應症拓展三個階段,共入組192例患者,包括小細胞肺癌(SCLC)、食管鱗狀細胞癌(ESCC)、頭頸部鱗狀細胞癌(HNSCC)、結直腸癌(CRC)、神經內分泌癌(NEC)及其他腫瘤。患者接受SKB500 2-18mg/kg Q3W 劑量范圍給藥,並在12mg/kg及16mg/kg進行了劑量擴展和適應症拓展。


截至2026年3月31日,療效數據顯示:

  • SKB500在多種實體瘤類型中均觀察到抗腫瘤活性,包括SCLC、ESCC、HNSCC、胰腺導管腺癌(PDAC)、非小細胞肺癌(NSCLC)和鼻咽癌(NPC);在接受12mg/kg且隨訪≥6周的124例患者中,客觀緩解率(ORR)為42.7%,疾病控制率(DCR)為83.9%;
  • 在經治的SCLC患者(n=40)中,ORR為65.0%(95%CI:48.3, 79.4),中位無進展生存期(mPFS)為7.2個月(95%CI: 4.3, NE),DCR為95.0%,mDOR為5.8個月;
  • 在經治的ESCC患者(n=37)中,ORR為54.1%。



安全性方面,在12 mg/kg、16mg/kg劑量組的對比中,12mg/kg組顯示出更優的安全性特征,表現為更低的≥3級治療相關不良事件(TRAEs)和治療相關嚴重不良事件(TRSAEs),且導致永久停藥率低。在12 mg/kg組中,≥3級TRAE的發生率為32.3%,最常見的為血液學事件。



研究表明,SKB500具有廣譜的抗腫瘤活性,在SCLC、ESCC、HNSCC、PDAC等多種經治的晚期實體瘤中均有響應, 在SCLC患者中療效顯著。在12mg/kg劑量組中,SKB500顯示出更優的安全性特征,導致永久停藥率較低,且未發生治療相關死亡事件。

主要研究者吉林省腫瘤醫院劉海峰教授表示:「此次SKB500首次人體研究的積極結果公布,不僅初步證實了其作為新型B7-H3 ADC所具備的良好療效與可控的安全性特征,也提示其在多種實體瘤中的治療潛力,尤其為惡性程度高、後線治療選擇有限的SCLC帶來了治療曙光,為後續的臨床開發夯實了基礎。我們期待在後續試驗中進一步驗證其臨床價值。」

關於SKB500

SKB500是公司利用OptiDC™平台技術自主研發的一款靶向B7-H3的新型ADC藥物,采用定點可裂解連接子並搭載強效的拓撲異構酶I抑制劑。在臨床I期研究中,SKB500顯示出良好的療效和安全窗,擬用於治療多種晚期實體瘤。目前,SKB500聯合免疫加與不加化療一線治療廣泛期小細胞肺癌(ES-SCLC)的聯合用藥探索II期研究正在中國進行中。

關於科倫博泰

四川科倫博泰生物醫藥股份有限公司(簡稱「科倫博泰」,股票代碼:6990.HK)是科倫藥業控股子公司,專注於創新生物技術藥物及小分子藥物的研發、生產、商業化及國際合作。公司圍繞全球和中國未滿足的臨床需求,重點布局腫瘤、自身免疫和代謝等重大疾病領域,建設國際化藥物研發與產業化平台,致力於成為在創新藥物領域國際領先的企業。公司目前擁有30余個重點創新藥項目,其中4個項目8個適應症已獲批上市,1個項目處於NDA階段,10余個項目正處於臨床階段。公司成功構建了享譽國際的專有ADC及新型偶聯藥物平台OptiDC™,已有2個ADC項目5個適應症獲批上市,多個ADC或新型偶聯藥物產品處於臨床或臨床前研究階段。更多信息請訪問官網https://kelun-biotech.com/

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2026-06-02
20:59
雲頂新耀宣佈就希布替尼(EVER001)達成獨家授權許可與合作協議

  • 雲頂新耀與Travere Therapeutics達成獨家授權許可與合作協議,授予其EVER001(希布替尼,civorebrutinib)除大中華區及部分東南亞國家以外區域的獨家開發及商業化權益。
  • 根據協議,雲頂新耀將獲得1.125億美元的首付款,並有資格在最多五個適應症上獲得高達10.3億美元的開發、註冊及商業化里程碑付款。此外,公司還將基於EVER001的未來年度淨銷售額,獲得從高個位數至雙位數百分比的分級特許權使用費。
  • EVER001是雲頂新耀的新一代共價可逆布魯頓酪氨酸激酶(BTK)抑制劑,具備「一個可以開發多種適應症的藥物(pipeline-in-a-product)」的開發潛力,有望為全球逾1000萬患有原發性膜性腎病(PMN)、IgA腎病、微小病變性腎病(MCD)、局灶節段性腎小球硬化(FSGS)和狼瘡性腎炎等疾病的患者提供更多治療選擇,並展現出潛在的廣泛應用價值。
  • 此次合作將加速EVER001在多種免疫介導的腎臟疾病中的開發進程。EVER001計劃在PMN、免疫介導的FSGS及MCD等適應症中開展臨床研究,並有望進一步拓展至更多適應症領域。

上海2026年6月2日 /美通社/ -- 雲頂新耀(HKEX 1952.HK,以下簡稱「公司」),一家專注於創新藥研發、臨床開發、製造及商業化的生物製藥公司,今日宣佈公司與Travere Therapeutics, Inc.(NASDAQ: TVTX,以下簡稱「Travere Therapeutics」)達成獨家授權許可與合作協議。根據協議,Travere Therapeutics將獲得EVER001(希布替尼,civorebrutinib)除大中華區及部分東南亞國家以外區域的獨家開發及商業化權益。此次合作將加速EVER001的全球臨床開發與商業化進程,為全球腎病患者帶來創新治療選擇。

根據協議,雲頂新耀將獲得1.125億美元的首付款,並有資格在最多五個適應症上獲得高達10.3億美元的開發、註冊及商業化里程碑付款。此外,公司還將基於EVER001的未來年度淨銷售額,獲得從高個位數至雙位數百分比的分級特許權使用費。該交易將在滿足特定交割條件及完成必要監管程序後完成交割。

EVER001是雲頂新耀的新一代共價可逆布魯頓酪氨酸激酶(BTK)抑制劑,具備「一個可以開發多種適應症的藥物(pipeline-in-a-product)」的開發潛力。與共價不可逆BTK抑制劑相比,EVER001作為一款潛在的同類最佳產品,在保持高活性的同時具有高選擇性,避免持續抑制帶來的毒副作用。目前,全球尚無藥物獲批用於原發性膜性腎病治療。現有傳統免疫抑制劑治療效果存在局限,且部分患者在停藥後易復發,同時伴隨一定不良反應,臨床仍存在未滿足的治療需求。

此前公佈用於治療中國PMN患者的1b/2a期臨床研究數據顯示,EVER001展現出快速、深度且持久的免疫學和臨床緩解,停藥後仍持續獲益,安全性高,耐受性強。這些結果支持EVER001具有治療以蛋白尿為特徵的自身免疫性腎小球疾病的潛力。

EVER001具備在多種免疫介導性腎小球疾病中的開發潛力,包括PMN、IgA腎病、MCD、FSGS及狼瘡性腎炎等。這類疾病均與異常免疫反應引發的腎小球損傷相關,可導致蛋白尿和腎功能下降,嚴重時甚至可能發展至終末期腎病,需要透析或腎移植治療。EVER001有望為全球逾1000萬名相關患者提供新的治療選擇。目前,EVER001計劃在PMN、免疫介導的FSGS及MCD等適應症中開展臨床研究,並有望進一步拓展至更多適應症領域。

雲頂新耀董事會主席吳以芳表示:「我們非常高興與Travere Therapeutics達成此次合作。這一合作將加速EVER001的全球開發與商業化進程,進一步釋放其在自身免疫性腎臟疾病領域的臨床潛力與商業價值,為全球患者帶來更多創新治療選擇。

作為潛在同類最佳創新藥物,EVER001已在原發性膜性腎病等自身免疫性腎臟疾病治療中展現出積極潛力。憑借其差異化作用機制,EVER001具備拓展至多種自身免疫性腎臟疾病的潛力,持續釋放其臨床開發潛力。

公司始終堅持'BD合作+自主研發'雙輪驅動戰略,持續推進戰略性業務拓展與自主研發,不斷完善全球研發體系建設,持續提升在全球創新藥領域的綜合競爭力。Travere Therapeutics在美國已有獲批的腎科產品,在腎病藥物開發、註冊及商業化方面積累了豐富經驗與成熟能力。雙方將充分發揮各自優勢,共同推進EVER001在原發性膜性腎病、免疫介導的局灶節段性腎小球硬化及微小病變性腎病上的全球臨床開發,為全球患者帶來更多突破性治療選擇。」

Travere Therapeutics總裁兼首席執行官Eric Dube博士表示:「EVER001是公司罕見腎病管線的重要戰略性補充,並具有顯著的協同價值,有望成為覆蓋多種免疫介導罕見腎病的同類最佳療法。罕見腎病患者目前仍面臨巨大的未滿足臨床需求。我們認為,在IgA腎病和FSGS領域已取得的階段性進展僅是這一治療領域潛力釋放的開始。Travere Therapeutics致力於持續推動該領域的重要創新與突破,憑借在罕見腎病領域積累的深厚專業經驗、成熟的研發與商業化能力,以及對患者的持續承諾,我們將不斷推動創新,為患者帶來更多突破性治療選擇。

作為一款具有差異化優勢的口服可逆BTK抑制劑,EVER001在原發性膜性腎病中已展現出令人鼓舞的概念驗證數據,其作用機制可覆蓋免疫介導的局灶節段性腎小球硬化、微小病變腎病等更多疾病領域。我們相信,EVER001將為罕見腎病患者帶來更具重要意義的治療突破,進一步推動該領域治療格局的重塑。」

原發性膜性腎病為成人腎病綜合征常見的病理類型,在中國的患病率呈逐年升高的趨勢,是發病率僅次於IgA腎病的原發性腎小球腎炎1。目前我國約有200萬原發性膜性腎病患者。超過1/3的原發性膜性腎病患者最終將進展為終末期腎病,全球亟需研發能提高治療緩解率、降低高復發率、減少慢性腎毒性風險的治療藥物。未來,雲頂新耀將攜手合作夥伴加速推進EVER001的全球開發與價值轉化,並在其他適應症領域共同推動後續研發。公司將持續提升在全球創新藥領域的綜合競爭力,為中國及全球患者帶來更多突破性治療方案。

EVER001由蘇州信諾維醫藥自主研發,並於2021年9月與中國抗體(3681.HK)共同授予雲頂新耀在全球範圍內腎臟疾病領域開發和商業化的權利。

參考文獻:
1. 利妥昔單抗在膜性腎病中應用的專家共識,中華內科雜誌2022年3月第61卷第3期。

關於EVER001(希布替尼)
EVER001膠囊(又名:XNW1011)是一款新一代共價可逆的布魯頓酪氨酸激酶(BTK)抑制劑,由蘇州信諾維醫藥自主研發,並於2021年9月與中國抗體(3681.HK)共同授予雲頂新耀在全球範圍內腎臟疾病領域開發和商業化的權利。該產品正在全球範圍內開發用於治療腎病。BTK是B細胞受體信號通路的重要組成部分,可調節B淋巴細胞的存活、激活、增殖和分化。因此,應用小分子抑制劑靶向BTK是治療B細胞淋巴瘤和自身免疫性疾病的有效選擇。

關於雲頂新耀
雲頂新耀是一家專注於創新藥研發、臨床開發、製造和商業化的生物製藥公司,致力於滿足全球市場尚未滿足的醫療需求。雲頂新耀的管理團隊在中國及全球領先製藥企業擁有深厚的專長和豐富的經驗。公司在浙江嘉善擁有具備商業化規模的全球生產基地,並依據中國、美國及歐盟標準建立了完善的GMP生產質量管理體系。

公司聚焦自身免疫、眼科、急重症及CKM(心血管、腎臟及代謝)等疾病治療領域,已打造集全渠道商業化體系與藥品全生命週期商業化能力於一體的商業化平台,並以擁有全球權益的自研mRNA平台為基礎,持續推進mRNA in vivo CAR-T與mRNA腫瘤疫苗等現有管線,同時通過引進及生態孵化潛力平台,拓展研發能力,同時強化全球化佈局,加快國際化發展進程。更多信息,請訪問公司官網:www.everestmedicines.com

關於 Travere Therapeutics

Travere是一家生物製藥公司,其使命是「專注罕病,終身承諾(In Rare For Life)」。團隊日復一日地齊心協力,幫助來自不同背景的患者、家庭及照護者應對罕見疾病帶來的生活挑戰。在這條道路上,Travere深知治療選擇的需求刻不容緩,因此Travere的全球團隊與罕見疾病社群合作,共同識別、開發及提供改變生命的療法。為實踐此使命,Travere持續尋求理解罕見疾病患者的不同觀點,勇敢開闢新路徑,以改變其生活並帶來希望——無論是今天還是未來。有關更多資料,請參閱 travere.com

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20:27
Everest Medicines Enters into Exclusive Licensing Agreement with Travere Therapeutics for Civorebrutinib a Potential Best-in-Class BTK Inhibitor for Rare Kidney Diseases

  • Civorebrutinib is an investigational oral, covalent reversible BTK inhibitor designed to provide differentiated efficacy, safety and convenience in immune-mediated kidney diseases
  • Civorebrutinib adds pipeline-in-a-product potential across multiple rare kidney diseases, expanding and diversifying Travere's pipeline

SHANGHAI, June 2, 2026 /PRNewswire/ -- Everest Medicines (HKEX 1952.HK, "Everest", or the "Company"), a biopharmaceutical company focused on the discovery, clinical development, manufacturing, and commercialization of innovative therapeutics, today announced that it has entered into an exclusive licensing and collaboration agreement with Travere Therapeutics, Inc. (NASDAQ: TVTX) for the development and commercialization of civorebrutinib (also known as EVER001), a potential best-in-class oral, covalent reversible Bruton's tyrosine kinase (BTK) inhibitor in all markets outside China and certain countries in East and Southeast Asia.

"This collaboration with Travere brings together deep expertise in kidney disease development and commercialization and we look forward to advancing civorebrutinib in primary membranous nephropathy, immune-mediated FSGS, and minimal change disease, delivering transformative therapies for patients with serious kidney diseases worldwide," said Mr. Yifang Wu, Chairman of the Board of Everest Medicines. "As a differentiated, potential best-in-class therapy, civorebrutinib has demonstrated encouraging efficacy in primary membranous nephropathy. With its highly selective and reversible covalent mechanism of action, it is well positioned to advance in development across multiple immune-mediated kidney indications. Everest remains committed to our dual-engine strategy of business development partnerships and in-house R&D. This collaboration will accelerate the global development and potential commercialization of civorebrutinib, expanding its clinical and future commercial value in autoimmune kidney diseases and the ability to deliver more innovative treatment options to patients."

"Civorebrutinib represents a strategic and complementary addition to our rare kidney disease portfolio, with the potential to become a best-in-class therapy across multiple immune-mediated rare kidney diseases," said Eric Dube, Ph.D., president and chief executive officer of Travere Therapeutics. "Patients living with rare kidney diseases still face significant unmet need, and we believe the progress made to date in IgAN and FSGS is only the beginning of what is possible for these communities. Travere has helped to deliver important firsts in these diseases, and we believe our expertise, infrastructure and deep commitment to the rare kidney community position us well to continue advancing innovation for patients. With proof-of-concept data in primary membranous nephropathy, a differentiated profile as an oral, reversible BTK inhibitor, and expected broad mechanistic applicability across diseases such as immune-mediated FSGS, minimal change disease and beyond, we believe civorebrutinib has the potential to meaningfully advance the treatment paradigm for rare kidney disease patients."

Civorebrutinib is an investigational oral, covalent reversible BTK inhibitor designed to provide differentiated efficacy, safety and convenience for patients with rare, immune-mediated kidney diseases, including primary membranous nephropathy (PMN), with planned evaluation in focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD) and potentially additional indications. BTK is a key mediator of B-cell receptor signaling and plays an important role in B-cell activation, maturation, proliferation, and differentiation into antibody-producing cells.

In immune-mediated kidney diseases, B-cell activation and autoantibody production are believed to contribute directly to kidney injury. Civorebrutinib has demonstrated proof of concept in a Phase 1/2 clinical trial of patients with PMN. The previously reported Phase 1/2 data demonstrated rapid and sustained reductions in anti-PLA2R autoantibodies and proteinuria, with high rates of immunologic and clinical remission and stable kidney function through 52 weeks of follow-up. Civorebrutinib has been generally well tolerated throughout the development program to date.

As innovation in rare kidney diseases continues to accelerate, patients still face significant unmet need and limited treatment options across many serious conditions. Civorebrutinib has the potential to serve as a pipeline-in-a-product across multiple immune-mediated kidney diseases. Travere plans to investigate civorebrutinib in PMN, immune-mediated FSGS and MCD, with the potential for additional indications. These diseases share immune-mediated mechanisms that can lead to glomerular damage, resulting in proteinuria and impaired kidney function that may ultimately require dialysis or transplant. Civorebrutinib may also broaden future treatment approaches in FSGS, where both nephroprotective and targeted immune control approaches may play important roles.

Under the terms of the agreement, Everest will receive an upfront payment of $112.5 million in exchange for granting Travere exclusive development and commercialization rights for civorebrutinib in all markets outside of China and certain countries in East and Southeast Asia. Everest is also eligible to receive up to approximately $1.03 billion in additional cash payments tied to specified clinical development, regulatory and commercial milestones across up to five indications. Travere will also pay tiered royalties on future sales in its licensed territories, ranging from high single-digit to double-digit percentages based on annual net sales thresholds. The license agreement will become effective upon satisfaction of customary conditions, including expiration or termination of the applicable waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended.

Conference Call Information

Travere Therapeutics will host a conference call and webcast today, Tuesday, June 2, 2026, at 8:30 a.m. ET. To participate in the conference call, dial +1 (833) 461-5787 (U.S.) or +1 (585) 542-9983 (International), conference ID 574 733 925 shortly before 8:30 a.m. ET. The webcast can be accessed on the Investor page of Travere's website at ir.travere.com/events-and-presentations. Following the live webcast, an archived version of the call will be available for 30 days on the Company's website. 

About Civorebrutinib

Civorebrutinib (also known as EVER001) is a next-generation covalent reversible Bruton's tyrosine kinase (BTK) inhibitor in development globally for the treatment of renal diseases. BTK is an essential component of the B-cell receptor signaling pathways that regulate the survival, activation, proliferation, and differentiation of B lymphocytes. Targeting BTK with small molecule inhibitors has been demonstrated to be an effective treatment option for B-cell autoimmune diseases.

About Everest Medicines

Everest Medicines is a biopharmaceutical company focused on discovering, developing, manufacturing and commercializing innovative pharmaceutical products that address critical unmet medical needs for patients in global markets. The management team of Everest Medicines has deep expertise and an extensive track record both in China and with leading global pharmaceutical companies.

The Company's therapeutic areas of focus include CKM (cardiovascular, kidney, and metabolic), autoimmune, ophthalmology and critical care. Everest Medicines has developed a fully integrated commercialization platform that combines omnichannel commercial capabilities with end-to-end product lifecycle management. Leveraging its proprietary mRNA platform, the Company is advancing its existing pipeline, including mRNA in vivo CAR-T and mRNA cancer vaccines, while selectively expanding into additional high-value therapeutic areas with blockbuster potential, and accelerating its global expansion. For more information, please visit the Company's website: www.everestmedicines.com.

About Travere Therapeutics

Travere is a biopharmaceutical company with its mission ''In Rare For Life'', and that comes together every day to help patients, families and caregivers of all backgrounds as they navigate life with a rare disease. On this path, Travere knows the need for treatment options is urgent — that is why Travere's global team works with the rare disease community to identify, develop and deliver life-changing therapies. In pursuit of this mission, Travere continuously seeks to understand the diverse perspectives of rare patients and to courageously forge new paths to make a difference in their lives and provide hope — today and tomorrow. For more information, visit travere.com.

Forward-Looking Statements
This news release may make statements that constitute forward-looking statements, including descriptions regarding the intent, belief or current expectations of the Company or its officers with respect to the business operations and financial condition of the Company, which can be identified by terminology such as "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "confident" and similar statements. Such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, or other factors, some of which are beyond the control of the Company and are unforeseeable. Therefore, the actual results may differ from those in the forward-looking statements as a result of various factors and assumptions, such as future changes and developments in our business, competitive environment, political, economic, legal and social conditions. The Company or any of its affiliates, directors, officers, advisors or representatives has no obligation and does not undertake to revise forward-looking statements to reflect new information, future events or circumstances after the date of this news release, except as required by law.

This press release is issued in both Chinese and English. In the event of any inconsistency, discrepancy or ambiguity between the Chinese version and the English version, the Company disclaims any liability arising from any translation, interpretation or understanding differences.

 

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15:49
Arm May Achieve USD15B In-house AI Chip Sales Target Ahead of Schedule

Arm Holdings plc (ARM.US) CEO Rene Haas said the company may achieve its USD15 billion in-house chip sales target earlier than expected, reflecting stronger-than-anticipated demand driven by the AI boom.

Arm had announced in March this year its plan to sell its own chips for the first time. Meta Platforms, Inc. (META.US) will become the first major customer of the chip, named AGI CPU.
~

AASTOCKS Financial News
Website: www.aastocks.com

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14:57
Ping An Launches "Ping An Home" Service Brand

Advancing Proactive Health Management to Meet Chinese Families' Demand for Healthy Longevity

HONG KONG and SHANGHAI, June 2, 2026 /PRNewswire/ -- As population aging accelerates and medical standards continue to advance, China is steadily entering an era of longevity. While life expectancy is increasing, improving quality of life has become a key concern for society at large.

Against this backdrop, Ping An Insurance (Group) Company of China, Ltd. ("Ping An" or the "Group"; HKEX: 2318 / 82318; SSE: 601318) continues to advance its "Integrated Finance + Health and Senior Care" strategy with the launch of the "Ping An Home" service brand. Centered on proactive health management, "Ping An Home" transforms the concept of healthy longevity into practical, family‑oriented health services embedded in daily life, extending insurance from post‑event risk compensation to full‑lifecycle health support.

In parallel, PKU Healthcare Group, a Ping An subsidiary, recently partnered with Fudan University to establish the Joint Research Center of Longevity Medicine, further strengthening research in longevity medicine.

Upgrading Insurance Services from Post-Event Payouts to Proactive Health Management
Ping An is actively integrating proactive health concepts into home‑based scenarios. Recently, Ping An Life and Ping An Good Doctor jointly launched the "Ping An Home" service brand to address families' growing demand for healthy longevity. The service offers proactive health management solutions covering key lifestyle areas such as sleep, nutrition, and exercise.

Focusing on "managing diet, sleep, and exercise at home," "Ping An Home" combines smart‑device monitoring, professional medical support, and continuous follow‑up management. This integrated approach helps families build more scientific and sustainable healthy lifestyles, shifting health management from reactive treatment to daily prevention.

Key services under "Ping An Home" also include:

  • Multi-Disease Integrated Management Services: providing comprehensive solutions covering disease management, medication management, lifestyle guidance, and end‑to‑end support.
  • Medical Care Concierge Services: including assistance with specialist appointment booking, online and offline medical accompaniment, and post‑treatment rehabilitation guidance.
  • Global Medical Consultation and Medication Access Services: connecting users with high‑quality medical and pharmaceutical resources in China and overseas.
  • Smart Home Protection Services: delivering all‑day, whole‑home, and all‑scenario protection through smart devices.

According to data from the National Health Commission of People's Republic of China and the World Health Organization, average life expectancy in China has approached 79 years, while healthy life expectancy remains at approximately 68 years, meaning individuals spend more than a decade living with illness or disability. Research also shows that less than 20% of healthy longevity is determined by genetics, while over 80% is closely linked to lifestyle factors such as diet, sleep, and exercise.

Cai Ting, Vice Chairman and Vice President of Ping An Life, commented, "longevity is not the ultimate goal. Healthy longevity is. Healthy lifestyles should begin in midlife. Scientifically managing health while the body is still strong is, in essence, about extending healthy life expectancy."

He emphasized that insurance services should go beyond financial compensation after risks occur and instead provide end-to-end planning and protection for customers' healthy living and healthy longevity, truly extending families' health spans.

He Mingke, Chief Executive Officer of Ping An Good Doctor, noted that as the primary service provider of "Ping An Home", the company will combine warm technology, the depth of long‑term service experience, and evidence‑based medical expertise to deliver 24/7, multi‑scenario, full‑lifecycle health protection, enabling proactive health management to become a natural part of everyday family life.

Ping An Home is not a standalone service, but a comprehensive proactive health management system integrating insurance, medical resources, and digital technology. It reflects the Group's years of practice in developing a China-style managed care model, aimed at reducing disease risks and delaying the onset of chronic conditions.

Advancing Longevity Medicine Research to Support Proactive Health Management
Recently, PKU Healthcare Group, together with Fudan University and Zhongshan Hospital affiliated with Fudan University, established the Joint Research Center of Longevity Medicine. The center serves as a platform integrating scientific research, clinical application, and industry collaboration.

Leveraging academic research strengths and clinical expertise, together with Ping An's capabilities in industrial transformation and insurance payment mechanisms, the center will focus on areas such as aging risk assessment, precision health interventions, and full‑lifecycle digital health management. These efforts aim to provide scientific support for the professionalization and standardization of future health management services.

The establishment of the research center represents a key step in implementing Ping An's "Integrated Finance + Health and Senior Care" strategy. Longevity medicine plays an important role in addressing population aging and extending healthy life expectancy. Through industry–academia–research collaboration, Ping An aims to accelerate the translation of cutting‑edge longevity research into real‑world applications, extending insurance services from traditional protection to comprehensive, full‑lifecycle health support.

Building a Comprehensive Family Health Support System
From launching the "Ping An Home" service brand to establishing a longevity medicine research platform, Ping An is progressively integrating scientific research, medical services, and protection mechanisms to build a full-lifecycle family health support system covering health, medical care, and elderly care.

Looking ahead, the Group will continue to deepen its "Integrated Finance + Health and Senior Care" strategy, delivering services with greater professionalism and human warmth to provide long-term support for families' healthy living.

About Ping An Insurance (Group) Company of China, Ltd.

Ping An Insurance (Group) Company of China, Ltd. (HKEX:2318 / 82318; SSE:601318) is one of the largest financial services companies in the world. It strives to become a world-leading provider of integrated finance, health and senior care services. Under the technology-enabled "integrated finance + health and senior care" dual-pronged strategy, the Group provides professional "financial advisory, family doctor, and senior care concierge" services to its over 250 million retail customers. Ping An advances intelligent digital transformation and employs technologies to improve financial businesses' quality and efficiency and enhance risk management. The Group is listed on the stock exchanges in Hong Kong and Shanghai. As of the end of December 2025, Ping An had more than RMB13 trillion in total assets. The Group ranked 27th in the Forbes Global 2000 list in 2025, 47th in the Fortune Global 500 list in 2025, and ranked AAA in MSCI ESG Ratings in 2025.

For more information, please visit the www.group.pingan.com and follow our LinkedIn page - PING AN.

 

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14:55
晶泰科技賦能希格生科再獲IND:強活性 pan-TEAD抑制劑SIGX2649臨床潛力凸顯,AI+類器官模式持續驗證

深圳2026年6月2日 /美通社/ -- 近日,晶泰科技(2228.HK)與孵化企業希格生科(Signet Therapeutics)再度迎來合作里程碑,雙方合作發現的泛 TEAD(pan-TEAD)抑制劑 SIGX2649 提前獲得美國食品藥品監督管理局(FDA)的新藥臨床試驗申請(IND)批件,計劃最早於今年第三季度開啟 I 期臨床試驗。SIGX2649 是第一款全覆蓋 TEAD 家族全部 4 種亞型的強活性 Pan-TEAD 抑制劑,有望成為全球首個上市的靶向 Hippo 通路的泛 TEAD 抑制劑,在實體瘤治療領域擁有廣闊市場。繼全球首款瀰漫性胃癌靶向藥 SIGX1094 獲批進入臨床後,晶泰科技與希格生科第二條創新管線提前獲批,標誌著 「AI+類器官」 藥物研發策略持續獲得臨床驗證,成功模式得以複製。

此次 SIGX2649 提前 IND 獲批,充分體現了該管線的臨床急需性。其核心臨床前研究數據展現出優異的成藥性、安全性與差異化的臨床價值。同時,廣東省人民醫院首席專家、中國肺癌精準治療領軍人物吳一龍教授將正式擔任 SIGX2649 的 I 期臨床,和 SIGX1094 聯合 KRAS-G12C 抑制劑 I/II 期臨床的首席研究者(Leading PI),加速推進兩大核心管線的全球開發。

晶泰科技與希格生科多個在研管線的連續成功,有力印證了其底層研發平台 「從算法到臨床」 的快速轉化能力,以及 「AI+類器官」 模式在攻堅高價值、創新靶點藥物開發中的巨大潛力。根據雙方協議,晶泰科技有權獲得 SIGX2649 最高達兩位數比例的商業化收益分成。

TEAD 蛋白是 Hippo 信號通路的核心節點,該通路與 P53、RAS 等並列為核心腫瘤驅動通路,在間皮瘤、肝癌、肺癌等實體瘤治療中具有廣闊前景,但長期缺乏有效藥物。TEAD 蛋白家族存在四種功能與表達模式各異的亞型,其抑制劑需在強效抑制各亞型與安全性之間取得平衡,極具挑戰性。目前全球範圍內尚無 TEAD 抑制劑獲批上市,最快在研產品亦處於 I 期臨床階段。

SIGX2649 是晶泰科技與希格生科基於 「AI+類器官」 模式合作研發的泛 TEAD(TEAD 1-4)抑制劑,可同時靶向 TEAD 家族全部 4 種亞型,展現出廣闊的臨床開發前景。其雙重作用機制,在抑制 TEAD 棕櫚酰化的同時增強 VGLL4 與 TEAD 的結合,能進一步放大該藥對 YAP/TEAD 功能的抑制。臨床前研究顯示,SIGX2649 在體外多種腫瘤模型(包括肝癌類器官、間皮瘤等)中表現出優異的抗增殖活性,體內抑瘤效果顯著,藥代動力學良好,且腎靶向毒性低於同類在研藥物,擁有差異化的臨床優勢與同類最佳(Best-in-class)的治療潛力。

SIGX2649 有望在小細胞肺癌,間皮瘤以及肝癌等存在顯著未滿足臨床需求的晚期實體瘤中發揮巨大的療效潛能。此外,它與 RAS 通路抑制劑聯用,在 KRAS 突變實體瘤中如非小細胞肺癌以及腸癌中展現出顯著協同效應。基於上述優異數據,SIGX2649 的核心臨床前研究已入選全球最具權威和影響力的癌症研究學術盛會——美國癌症研究協會(AACR)2026年年會報告。

在 SIGX2649 的發現過程中,晶泰科技基於量子物理、AI 與自動化合成平台,實現了虛擬篩選與物理合成的快速閉環。晶泰科技首先通過 AI 生成百萬級分子庫,並利用計算化學對活性、亞型選擇性、結構新穎性及可合成性等關鍵性質進行多維評估,將分子庫快速收斂至百級;隨後依靠機器人驅動的大規模化學合成與測試,高效完成 「設計-合成-測試-分析」(DMTA)閉環驗證。在此基礎上,晶泰科技結合希格生科的類器官模型篩選,獲得骨架新穎的先導化合物,經物理模型與 AI 聯合的 ADMET 迭代優化,最終通過體內藥效與安全性驗證,確定 SIGX2649 為臨床前候選化合物(PCC)。

此前,晶泰科技與希格生科合作研發的全球首款 「AI+類器官」 新藥,也是首款進入臨床階段的 FAK/SRC 雙靶點抑制劑 SIGX1094,已獲美國 FDA 授予孤兒藥資格認定與快速通道資格,並獲得 2025 年蓋倫獎(Prix Galien USA)提名,目前正在北京大學腫瘤醫院開展瀰漫性胃癌 I 期臨床試驗,並即將啟動 II 期。該分子從發現到 IND 的推進節奏與質量,為 SIGX2649 的快速獲批提供了直接的經驗復用與平台驗證。兩個分子在 「AI+類器官」 研發模式下先後進入臨床,且第二個管線提前獲批,再次證實了晶泰科技與希格生科的 「AI+類器官」 平台合作模式在分子生成、選擇性優化及成藥性評估環節具備可復現、可規模化的技術優勢。

將擔任 SIGX2649 的 I 期臨床及 SIGX1094 聯合 KRAS-G12C 抑制劑的 I/II 期臨床首席研究者的吳一龍教授,不僅是廣東省人民醫院首席專家,還是國際肺癌研究協會(IASLC)傑出科學獎獲得者,擁有肺癌精準治療研究近 40 年,曾推動多個靶向藥物在國內外獲批上市。吳一龍教授豐富的開發經驗、臨床推進能力和國際化視野將大幅加快兩款管線藥物臨床執行與全球註冊,加速為全球患者提供突破性的治療方案。

關於希格生科

希格生科是全球 「類器官+AI」 藥物研發模式的先行者,是深圳市專精特新企業,並獲得國家高新技術企業認定。公司最初誕生於哈佛大學校園,於 2020 年底正式落地深圳,至今已完成近 3 億元的融資及項目資助。目前公司具有四條藥物管線,首條管線開發全球首款瀰漫性胃癌靶向藥 SIGX1094,先後獲得了美國 FDA 和中國 NMPA 的 IND 批件,並獲得美國 FDA 孤兒藥資格認定及快速通道認定,已邁入一期臨床試驗階段。希格不僅是 Signet 的音譯,而且秉承 「希冀滿懷,格物致知」 的願景,公司利用接近病人基因組學特徵的類器官疾病模型在藥效評價及新靶點發現中的關鍵作用,結合 AI 人工智能篩選、合成和優化小分子化合物,開發 first-in-class 創新靶向藥。2025 年 4 月,美國 FDA 正式發佈聲明,明確支持類器官和 AI 技術逐步替代傳統動物實驗,充分驗證了其技術佈局的前瞻性與科學性。

關於晶泰科技

晶泰科技(「XtalPi Holdings Limited」,股份簡稱:晶泰控股,XTALPI,股票代碼:2228.HK)由三位麻省理工學院的物理學家於 2015 年創立,是一個基於量子物理、以人工智能賦能和機器人驅動的創新型研發平台。公司採用基於量子物理的第一性原理計算、人工智能、高性能雲計算以及可擴展及標準化的機器人自動化相結合的方式,為製藥及材料科學(包括農業技術、能源及新型化學品以及化妝品)等產業的全球和國內公司提供藥物及材料科學研發解決方案及服務。

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14:54
晶泰科技研發食品級口服肽Tensotide™獲美國Self-GRAS認證,AI設計分子破局千億代謝健康消費品市場

深圳2026年6月2日 /美通社/ -- 全球領先的 AI+機器人藥物與材料研發平台企業晶泰科技(2228.HK)今日宣佈,依托其 AI 多肽開發平台 PepiX™,公司已成功自主開發了一款關注血糖健康管理的創新口服食品原料——多肽 Tensotide™,獲美國 Self-affirmed GRAS(一般認為安全)認定。這標誌著 Tensotide™ 屬於 「公認安全」的食品級原料,可在美國合法應用於食品及膳食補充劑產品中。這是繼公司此前成功推出的固發功效成分「雙子星」 多肽 AquaKine™ 和小分子 Remeanagen™ 之後,晶泰科技在消費健康領域實現的又一關鍵里程碑,再次驗證了其 AI 研發平台在消費品與食品原料成分開發方面的持續轉化能力。

晶泰科技研發食品級口服肽Tensotide™獲美國Self-GRAS認證
晶泰科技研發食品級口服肽Tensotide™獲美國Self-GRAS認證

以AI入局千億代謝健康管理市場,
破解口服產品的「不可能三角」

全球肥胖與高血糖人群持續激增,代謝健康已成為最剛性的消費需求之一。根據弗若斯特沙利文報告,全球減重保健食品市場 2025 年已突破 200 億美元,中國市場年複合增長率超過 14%。

當前,市場上的控糖減重產品普遍面臨 「有效的不安全、安全的效果弱、效果好的價格高」 的困局。GLP-1 類處方藥雖療效明確,但價格昂貴、需注射給藥,而口服制劑使用限制條件多,且整體存在胃腸與甲狀腺相關副作用警示,僅限醫囑範圍內使用,難以覆蓋大眾日常健康管理場景。在口服產品領域,各技術路線同樣存在明顯短板:傳統保健品如苦瓜素、白芸豆提取物等天然植物成分,作用機理模糊、臨床證據不足,效果難以標準化;普通功能肽及口服大分子蛋白多為天然片段,穩定性差、易被胃酸降解,難以在消化道中穩定發揮作用,產業化價值有限;小分子化學成分則受制於嚴格監管,難以進入日常消費場景。市場亟需更加安全、有效和日常可及的消費品級產品。

Tensotide™ 分子的設計正是針對這一市場缺口,兼具良好的效果、高穩定性、高安全性、成本可控易量產等差異化優勢。作為可加入食品和膳食補充劑的成分,它為控糖人群提供更加豐富的日常產品選項。立項之初,晶泰科技便選擇了經過豐富安全性與有效性驗證的生理學機制,以調節能量代謝通路、抑制碳水化合物的降解和吸收為核心機制,為有血糖管理需求的消費者提供一種可融入日常飲食的輔助方案。這一成分在動物模型上展現出良好的效果,最高可降低餐後血糖峰值達 30%。同時,Tensotide™ 在40℃環境下、強酸、強鹼及多種消化酶的耐受性方面表現出良好的穩定性,解決了長期困擾功能肽產業化的「口服難」問題,使其在健康補劑和食品添加劑應用場景中具備廣泛的適用性。

晶泰研發口服成分Tensotide™在動物模型上展現出良好的效果,最高可降低餐後血糖峰值達 30%
晶泰研發口服成分Tensotide™在動物模型上展現出良好的效果,最高可降低餐後血糖峰值達 30%

 * 以上實驗數據源自動物模型,該結果不代表產品實際功效,不代表人體使用效果,產品功效因人而異

目前,該成分已獲中國發明專利授權,並完成了 PCT 國際專利申請與公斤級工業化生產驗證,表明晶泰科技已打通口服功能肽從AI設計、合規申報到工業化量產的全鏈條,商業化條件趨於成熟。

晶泰研發口服成分Tensotide™強酸、強鹼及多種消化酶的耐受性方面表現優越,解決多肽開發的「口服難」問題
晶泰研發口服成分Tensotide™強酸、強鹼及多種消化酶的耐受性方面表現優越,解決多肽開發的「口服難」問題

 * 以上實驗數據源自小鼠模型動物,該結果不代表產品實際功效,不代表人體使用效果,產品功效因人而異

Tensotide™ 作為一種無色無味、安全性突出的口服功能肽,既可用於膳食補充劑開發,也可作為食品原料靈活添加至主食、零食、飲料等滿足消費者低升糖(GI)飲食需求的日常消費品中。食品原料的價格體繫在普惠性上具有天然優勢,具備快速滲透市場的潛力,適用人群更廣泛。Tensotide™ 憑借其合規資質、安全性與應用靈活性,有望成為大健康消費品的新一代標誌性功能原料。

從化妝品到食品:
消費品領域的持續突破

Tensotide™ 的獲批並非晶泰科技首次將 AI 平台能力拓展至消費健康領域。此前,公司已成功將基於 AI 設計篩選的固發功效成分註冊為化妝品成分——多肽 AquaKine™ 和小分子 Remeanagen™;基於這兩款成分開發的 Groland 高嵐頭皮煥活精華曾獲天貓防脫新品榜第一名,並於近日入選 Instyle 雜誌第八屆美妝必買榜單。

此次 Tensotide™ 獲得國際食品原料合規認定,將晶泰科技在消費品功效成分領域的佈局從美妝個護進一步延伸至膳食健康,標誌著晶泰科技 AI 平台在醫藥、化妝品、膳食補充劑三大領域實現了技術復用與商業閉環。

這種跨賽道的拓展,展現了晶泰科技將同一套 AI+機器人底層能力在不同市場需求與合規路徑下進行高效遷移的系統性優勢。通過優先聚焦產品的安全性和使用體驗,公司將其前沿的分子設計能力應用於創新型化妝品功效成分和食品成分的發現與開發,能夠以更短的合規路徑進入市場空間巨大、現金流清晰的消費品領域。這為晶泰科技在藥物研發主線之外,構建了一條具有高潛力的第二增長曲線。

晶泰科技董事局主席溫書豪博士表示:「Tensotide™ 獲得美國權威認證,是 PepiX™ 平台在消費健康領域的一次重要驗證。它證明我們能夠運用製藥級別的分子開發能力,高效交付安全、可及的日常健康解決方案。這不僅是單個分子的突破,更代表了一片藍海市場——讓 AI 驅動的精準分子設計,開發出真正滿足大眾需求的產品,讓 AI 的技術普惠真正改善人們的生活。」

隨著 Tensotide™、AquaKine™、Remeanagen™ 三款分子的監管認證與商業化落地,晶泰科技已構建起覆蓋代謝健康與美容抗衰的消費健康雙賽道矩陣。未來,晶泰科技將持續拓展抗衰老、血脂管理、尿酸管理等熱點領域的消費品成分開發,針對大眾在健康與美容方面的核心市場需求,以高標準研發平台持續設計產出高安全性、滿足日常使用場景的功能分子,逐步將健康管理與年輕化從醫療場景延伸至日常消費場景,為大眾帶來效果明確的好產品。

PepiX™AI平台賦能:
將功能肽發現帶入工程化時代

Tensotide™ 的成功並非偶然,它再次驗證了晶泰科技 PepiX™ AI 多肽開發平台從源頭創新、精準設計到產業落地的全鏈條能力。傳統多肽研發高度依賴 「試錯法」,普遍面臨設計盲目、穩定性差、產業化難三大瓶頸——分子命中率不足 5%,研發週期長達 1 至 3 年,且天然肽易被酶解、合成成本高、難以穩定量產。

PepiX™ 平台融合了生成式AI分子設計、自動化合成與高通量濕實驗篩選三大核心能力,形成了 「干實驗設計+濕實驗驗證」 的高效閉環。在設計端,AI 算法能夠在廣闊的序列空間中同步優化穩定性、靶點親和力與口服利用度;在驗證端,規模化並行的自動化機器人工作站可實現數千個候選分子的快速合成與活性測試,使研發週期從數年縮短至數月。正是這一工程化的研發體系,使得Tensotide™以醫藥級平台的高標準開發,實現了食品級的安全性保障。在保持高活性的同時,該多肽分子在不同酸鹼環境及多種酶作用條件下仍可保持較好的結構穩定性,可廣泛應用於各類食品基質中,成為極具競爭力的新一代口服功能性成分。在多肽合成環節,生產工藝已實現公斤級穩定量產,純度超過 95%,成本可控,具備大規模商業化條件。

PepiX™ 平台完整覆蓋 Hit(苗頭化合物)發現到 PCC(臨床前候選化合物)開發的多肽藥物發現流程,支持線性肽、環肽和雙環肽等多種分子類型。目前,PepiX™ 平台已實現多賽道技術落地,正在重點佈局腦部/眼部遞送、口服多肽、環肽等多種類型的高潛力多肽分子的開發。

關於晶泰科技

晶泰科技(「XtalPi Holdings Limited」,股份簡稱:晶泰控股,XTALPI,股票代碼:2228.HK)由三位麻省理工學院的物理學家於 2015 年創立,是一個基於量子物理、以人工智能賦能和機器人驅動的創新型研發平台。公司採用基於量子物理的第一性原理計算、人工智能、高性能雲計算以及可擴展及標準化的機器人自動化相結合的方式,為製藥及材料科學(包括農業技術、能源及新型化學品以及化妝品)等產業的全球和國內公司提供藥物及材料科學研發解決方案及服務。

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10:31
LENOVO GROUP Once Leaps 8%+ to New High; Macquarie Lifts TP to HKD37.4, Says Valuation Re-rating Cycle Has Begun

LENOVO GROUP (00992.HK) opened 2.85% higher today and once surged 8.6% to a record high of HKD27.42. It last quoted at HKD26.04, up 3.17%, with turnover of 136 million shares, involving HKD3.617 billion.

Macquarie said in a research report that LENOVO GROUP's recent results confirmed a structural inflection point, with its ISG returning to profit amid accelerating demand for AI and traditional servers. The broker believed AI server demand will continue to outpace supply, supporting strong ISG revenue growth and margin expansion.

Meanwhile, tight memory supply has become a tailwind, helping improve server pricing, market share gains and operating leverage. The broker viewed the recent share price rally as the beginning of a valuation re-rating cycle.

Macquarie noted that LENOVO GROUP's AI server pipeline has increased to USD21 billion (as of the end of FY2026 in March), providing strong earnings visibility.

Although its market share in the high-end enterprise infrastructure segment remains relatively small, the company should be able to start gaining share in the high-end market, as deliveries of NVIDIA Corporation (NVDA.US) GB300 began last quarter, and timely deliveries of NVIDIA Vera Rubin servers are expected in 2H26.

The broker largely lifted its TP by 72% from HKD21.75 to HKD37.4. It reiterated its Outperform rating and named the stock as a Marquee Buy idea.
~

AASTOCKS Financial News
Website: www.aastocks.com

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09:54
SK Group Chairman Meets NVIDIA CEO Jensen Huang to Discuss AI Memory Chip Co-op

SK Group Chairman Chey Tae-won met with NVIDIA Corporation (NVDA.US) CEO Jensen Huang in Taipei yesterday (1st), where the two exchanged views on cooperation in AI memory chips, South Korean media reported.

SK hynix posted on social media about the meeting between Chey and Huang and released photos from the event. The photos also showed SK hynix President Kwak Noh-jung and other senior executives from both companies attending the gathering.

The two sides reviewed their achievements in AI memory chips and reaffirmed their commitment to working together to open a new chapter in AI infrastructure development.

Huang later attended a dinner event hosted by South Korea, where he interacted with executives of South Korean enterprises.

In response to questions from South Korean media, Huang said the most critical elements of the HBM supply chain are performance, quality, reliability and supply capability, and therefore NVIDIA is working closely with SK.
~

AASTOCKS Financial News
Website: www.aastocks.com

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09:15
晶泰科技孵化虛擬細胞引擎 INFevo(無界進化)完成數千萬元天使輪融資,加速藥物新靶點發現與臨床轉化

北京2026年6月2日 /美通社/ -- 人工智能(AI)+機器人驅動研發創新的平台型企業晶泰科技(2228.HK)今日宣布,其深度孵化的前沿AI生物企業——無界進化(INFevo)已完成數千萬元天使輪融資,由順為資本、紅杉中國與松禾資本共同參與。INFevo 專注於構建基於 AI 的「虛擬細胞」系統(Virtual Cell System),旨在深度解碼生命語言,從而精准指引創新藥物發現與細胞工程化設計。

當前,生物醫藥研發普遍面臨臨床轉化率極低的困境。以中樞神經系統疾病、免疫疾病及抗衰老等復雜領域為例,研發成功率長期徘徊在 5% 至 8%。其根本原因在於,行業始終缺乏能夠代表並預測人體復雜系統的研究體系,而動物模型與人體之間存在巨大的物種差異,導致大量候選分子在臨床後期失敗。破解這一難題的關鍵,在於從靜態的結構認知走向動態的系統研究。科學界普遍認為,構建高保真虛擬細胞,是以系統級定量模擬跨越從實驗室到人體的預測鴻溝的關鍵技術。

為實現這一目標,INFevo 采用「全棧 AI 基礎大模型 + 高通量自動化實驗」的雙驅路徑,通過建立能夠預測遺傳、化學和環境擾動下細胞狀態演化的數字模型,並形成自我強化的「干濕閉環」,將虛擬細胞從科研概念加速推向工業級高效研發工具的進程。

自創立之初,INFevo便秉持全球化商業視野,直擊藥物研發的核心痛點,並已組建起一支兼具底層科學硬實力與工業交付經驗的跨界團隊。

作為晶泰科技內部孵化的戰略項目,INFevo 在藥物創新價值鏈上與晶泰形成高度協同。晶泰在小分子、大分子、多肽及核酸等領域具備「分子級」和「結構級」的高效設計與篩選能力,而 INFevo 則從「細胞級」和「系統生物學級」提供AI模型與轉化預測。二者的銜接,首使藥物發現鏈條上長期割裂的分子優化與轉化預測有望首次打通,極大深化雙方的能力護城河。

INFevo依托晶泰科技作為上市頭部科技企業的行業積澱、工程化交付底座與全球產業資源,得以快速跨越初創企業的平台建設階段。借助中國豐富的科研與多維臨床數據資源優勢,公司有望加速實現從前沿技術創新到全球商業落地的完整閉環,通過構建以AI+Biology 大模型為基礎的虛擬細胞模型,聯合全球制藥及生物工程合作伙伴,共同探索生命科學的「無界進化」。

關於無界進化(INFevo

北京無界進化科技有限公司(INFevo)致力於構建行業領先的AI虛擬細胞模型,為全球藥物創新提供變革性的生物學研究工具。公司整合生物領域最先進(SOTA)的自研基礎大模型OCOO與自動化、智能化的細胞實驗平台,打造全球領先的AI時代生物醫藥創新研究平台,從而有力支撐基礎生物學的科研突破。同時,公司還通過有效銜接臨床研究,加速創新成果的落地轉化。圍繞抗衰老、神經退行性疾病、自身免疫疾病、代謝疾病、腫瘤等具有挑戰性的研究方向,無界進化正加速建立起一套覆蓋新機制與新靶點發現、虛擬藥物篩選與評價,以及臨床方案優化的全功能AI生物學平台。

關於晶泰科技

晶泰科技(「XtalPi Holdings Limited」,股份簡稱:晶泰控股,XTALPI,股票代碼:2228.HK)由三位麻省理工學院的物理學家於 2015 年創立,是一個基於量子物理、以人工智能賦能和機器人驅動的創新型研發平台。公司采用基於量子物理的第一性原理計算、人工智能、高性能雲計算以及可擴展及標准化的機器人自動化相結合的方式,為制藥及材料科學(包括農業技術、能源及新型化學品以及化妝品)等產業的全球和國內公司提供藥物及材料科學研發解決方案及服務。

 

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