Multiple individuals were suspected to have had their credit cards stolen to order iPhones. In response to media inquiries, an Apple spokesperson said that all received orders would undergo review before processing. The company is expediting the identification and cancellation of any potentially submitted fraudulent transactions.

Apple's iPhone 18 Pro series officially began pre-orders on Saturday (12th). Police received reports from more than 700 people during Saturday and Sunday (13th), alleging that their credit cards were suspected to have been misused for online phone purchases, involving approximately HKD14.7 million. The largest single case involved about HKD114,000. No arrests have been made so far.
~

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CHENGDU, China, Sept. 14, 2026 /PRNewswire/ -- Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. ("Kelun-Biotech" or "the Company", 6990.HK) announced that results from the phase III registrational study of its novel human epidermal growth factor receptor 2 (HER2)-targeted antibody–drug conjugate (ADC) trastuzumab botidotin (舒泰莱^®) in HER2-positive unresectable or metastatic breast cancer (BC) have been published in Journal of Clinical Oncology (JCO, impact factor (IF)=44.7). Professor Xichun Hu and Professor Hongxia Wang of Fudan University Shanghai Cancer Center, and Dr. Junyou Ge, Director of the National Engineering Research Center of Targeted Biologics act as the co-senior authors. Professor Jian Zhang of Fudan University Shanghai Cancer Center, Professor Quchang Ouyang of Hunan Cancer Hospital, Professor Qingyuan Zhang of Harbin Medical University Cancer Hospital, Professor Huihui Li of Cancer Hospital of Shandong First Medical University, and Professor Xu Wang of Tianjin Medical University Cancer Institute and Hospital act as the co-first authors. These findings had previously been selected as a Late-Breaking Abstract (LBA) and presented as an oral presentation at the 2025 European Society for Medical Oncology (ESMO) Congress.

This randomized, open-label, multicenter phase III study was designed to evaluate the efficacy and safety of trastuzumab botidotin monotherapy versus trastuzumab emtansine (T-DM1) in patients with HER2-positive unresectable or metastatic BC who had received prior trastuzumab and taxane-containing regimens. A total of 365 patients were randomized 1:1 to receive trastuzumab botidotin or T-DM1. The primary endpoint was progression-free survival (PFS) assessed by blinded independent central review (BICR), and secondary endpoints included overall survival (OS), objective response rate (ORR), and duration of response (DoR).

As of the data cutoff date of April 26, 2025, with a median follow-up of 14.9 months, efficacy results showed:

• Median PFS was significantly prolonged in the trastuzumab botidotin group compared with the T-DM1 group (11.1 months vs. 4.4 months; hazard ratio (HR) = 0.39) (Figure A), meeting the primary endpoint of the study; consistent PFS benefit was observed across all prespecified subgroups (Figure B).
   
•  Trastuzumab botidotin group demonstrated deeper and more durable tumor responses compared with T-DM1 group, with an ORR of 76.9% vs. 53.0% and a median DoR of 12.2 months vs. 5.7 months (Figure C).
  
  
•  OS data were not mature in both groups, but an OS benefit trend was observed in trastuzumab botidotin group, demonstrating a 38% reduction in the risk of death (Figure D).

In terms of safety, patients in the trastuzumab botidotin group had a low incidence of interstitial lung disease (ILD), and the incidences of hematologic, hepatic, and gastrointestinal toxicities were notably lower than those in the T-DM1 group, along with lower rates of serious adverse events (SAEs) and treatment discontinuations. The most common treatment-related adverse events (TRAEs) in trastuzumab botidotin group were ocular events, which could be recovered or reversed after management with standardized strategies.

The publication of the phase III results for trastuzumab botidotin in Journal of Clinical Oncology marks a major international academic breakthrough for a domestically developed HER2 ADC backed by high-level clinical evidence. This is the first phase III trial in China for a HER2 ADC compared head-to-head with T-DM1 with positive results. The data showed that trastuzumab botidotin demonstrated improvements in key efficacy endpoints including PFS, ORR, and DoR, along with a favorable safety profile. Based on these positive results, trastuzumab botidotin has been approved by China's National Medical Products Administration (NMPA) for the treatment of second-line or later HER2-positive BC, becoming the first domestically developed HER2 ADC approved for this indication in China and providing a new treatment option for patients with HER2-positive advanced breast cancer.

About Trastuzumab botidotin(舒泰莱^®)

Trastuzumab botidotin is a differentiated HER2 ADC to treat advanced HER2+ solid tumors. As an innovative HER2 ADC developed by the Company, it conjugates a novel, monomethyl auristatin F (MMAF) derivative (a highly cytotoxic tubulin inhibitor, Duo-5) via a stable, enzyme-cleavable linker to a HER2 monoclonal antibody with a DAR of 2. Trastuzumab botidotin specifically binds to HER2 on the surface of tumor cells and is internalized by tumor cells, releasing the toxin molecule Duo-5 inside the cell. Duo-5 induces tumor cell cycle arrest in the G2/M phase, leading to tumor cell apoptosis. After targeting HER2, trastuzumab botidotin can also inhibit the HER2 signaling pathway; it has antibody-dependent cell-mediated cytotoxicity (ADCC) activity.

Based on the results of a multi-center, randomized, open-label, controlled Phase 3 KL166-III-06 study, trastuzumab botidotin was approved for marketing by the NMPA for adult patients with unresectable or metastatic HER2 positive BC who have received one or more prior anti-HER2 therapy. At a pre-specified interim analysis, trastuzumab botidotin monotherapy demonstrated a statistically significant and clinically meaningful improvement in the primary endpoint of PFS as assessed by the BICR compared with T-DM1; the beneficial trend for OS of trastuzumab botidotin was also observed.

Currently, the Company has initiated an open, multi-center Phase 2 clinical study of trastuzumab botidotin in the treatment of HER2+ unresectable or metastatic BC that previously received a topoisomerase inhibitor payload ADC.

About Kelun-Biotech

Kelun-Biotech (6990.HK) is a holding subsidiary of Kelun Pharmaceutical, which focuses on the R&D, manufacturing, commercialization and global collaboration of innovative biological drugs and small molecule drugs. Kelun-Biotech focuses on major disease areas such as solid tumors, autoimmune, inflammatory, and metabolic diseases, and in establishing a globalized drug development and industrialization platform to address the unmet medical needs in China and the rest of world. Kelun-Biotech is committed to becoming a leading global enterprise in the field of innovative drugs. At present, Kelun-Biotech has more than 30 ongoing key innovative drug projects, of which 4 projects with 8 indications have been approved for marketing, 2 projects with 3 indications are in the NDA stage and more than 10 projects are in the clinical stage. Kelun-Biotech has established one of the world's leading proprietary ADC and novel DC platforms, OptiDC™, and has 2 ADC projects with 5 indications approved for marketing, and multiple ADC and novel DC assets in clinical or preclinical research stage. For more information, please visit https://en.kelun-biotech.com/. 

成都2026年9月14日 /美通社/ -- 四川科倫博泰生物醫藥股份有限公司(下稱「科倫博泰」或「公司」 6990.HK)宣佈，新型靶向人類表皮生長因子受體2 (HER2)抗體偶聯藥物(ADC)博度曲妥珠單抗(舒泰萊^®)治療HER2陽性不可切除或轉移性乳腺癌(BC)的III期註冊性研究結果發表於國際腫瘤學權威期刊《臨床腫瘤學雜誌》(Journal of Clinical Oncology，影響因子(IF)=44.7)。復旦大學附屬腫瘤醫院胡夕春教授、王紅霞教授及生物靶向藥物國家工程研究中心主任葛均友博士為共同資深作者，復旦大學附屬腫瘤醫院張劍教授、湖南省腫瘤醫院歐陽取長教授、哈爾濱醫科大學附屬腫瘤醫院張清媛教授、山東第一醫科大學附屬腫瘤醫院李慧慧教授和天津醫科大學腫瘤醫院汪旭教授為共同第一作者。該研究結果此前已入選2025年歐洲腫瘤內科學會(ESMO)大會突破性摘要(LBA),並以口頭報告的形式發佈。

該研究是一項隨機、開放、多中心III期臨床研究，旨在評估博度曲妥珠單抗單藥對比恩美曲妥珠單抗(T-DM1)在既往接受過曲妥珠單抗和紫杉類治療的HER2陽性不可切除或轉移性BC患者中的療效和安全性。共365例患者按1:1隨機分配接受博度曲妥珠單抗或T-DM1治療，主要終點為盲態獨立中心評估(BICR)評估的無進展生存期(PFS)，次要終點包括總生存期(OS)、客觀緩解率(ORR)、緩解持續時間(DoR)等。

數據截至2025年4月26日，中位隨訪時間為14.9個月。療效數據顯示：

• 博度曲妥珠單抗組相較T-DM1組顯著延長中位PFS(11.1個月 vs 4.4個月；風險比(HR)=0.39)  (Figure A)，已達到研究的主要終點；且在所有預設亞組中均能觀察到一致的PFS獲益 (Figure B)；
• 博度曲妥珠單抗組相較T-DM1組展現出更深、更持久的腫瘤緩解效果，ORR為76.9% vs 53.0%，中位DoR為 12.2個月vs 5.7個月 (Figure C)。
• 兩組OS數據均未成熟，但博度曲妥珠單抗組已觀察到OS獲益趨勢，死亡風險降低38% (Figure D)；

安全性方面，博度曲妥珠單抗組患者的間質性肺病(ILD)發生率低，血液、肝臟及胃腸道毒性發生率明顯低於T-DM1組，嚴重不良事件(SAE)發生率及停藥率亦更低。此外，博度曲妥珠單抗組最常見的治療相關不良事件(TRAE)為眼部AE，可通過標準化策略管理後恢復或緩解。

博度曲妥珠單抗III期研究成果發表於《臨床腫瘤學雜誌》，意味著國產HER2 ADC依託高水平的臨床證據在國際學術領域取得了重要突破。該研究是中國首個HER2 ADC頭對頭對比T-DM1取得陽性結果的III期臨床研究，其數據表明，博度曲妥珠單抗在PFS、ORR及DoR等關鍵療效終點顯示出優勢，並表現出良好的安全性特徵。憑藉此積極結果，博度曲妥珠單抗已獲中國國家藥品監督管理局(NMPA)批准治療二線及以上HER2陽性BC患者，成為中國首個獲批該項適應症的國產HER2 ADC，為HER2陽性晚期BC患者提供了新的治療選擇。

關於博度曲妥珠單抗(舒泰萊^®)

博度曲妥珠單抗是一款用於治療晚期HER2陽性實體瘤的差異化HER2 ADC。作為一款由本公司開發的創新HER2 ADC，其通過穩定的酶可裂解連接子將新型單甲基奧瑞他汀F(MMAF)衍生物（高細胞毒性微管蛋白抑制劑Duo-5）與HER2單克隆抗體偶聯，藥物抗體比率為2。博度曲妥珠單抗特異性地結合腫瘤細胞表面的HER2，並被腫瘤細胞內吞，在胞內釋放毒素分子Duo-5。Duo-5誘導腫瘤細胞週期阻滯在G2/M期，引起腫瘤細胞凋亡。博度曲妥珠單抗靶向結合HER2後也可抑制HER2介導的信號通路；其具有抗體依賴細胞介導細胞毒作用(ADCC)活性。

基於一項多中心、隨機、開放標籤、對照III期KL166-III-06研究結果，博度曲妥珠單抗獲NMPA批准用於既往接受過一種或一種以上抗HER2藥物治療的不可切除或轉移性HER2陽性成人BC患者。在預設的期中分析中，與T-DM1相比，博度曲妥珠單抗單藥在主要研究終點——BICR評估的PFS方面實現統計學意義和臨床意義的顯著改善；亦觀察到博度曲妥珠單抗OS的獲益趨勢。

目前，本公司已啟動博度曲妥珠單抗用於治療既往接受過有效載荷為拓撲異構酶抑制劑ADC治療的HER2陽性不可切除或轉移性BC的開放、多中心II期臨床研究。

關於科倫博泰

四川科倫博泰生物醫藥股份有限公司(簡稱「科倫博泰」，股票代碼：6990.HK)是科倫藥業控股子公司，專注於創新生物技術藥物及小分子藥物的研發、生產、商業化及國際合作。公司圍繞全球和中國未滿足的臨床需求，重點佈局腫瘤、自身免疫和代謝等重大疾病領域，建設國際化藥物研發與產業化平台，致力於成為在創新藥物領域國際領先的企業。公司目前擁有30餘個重點創新藥項目，其中4個項目8個適應症已獲批上市，2個項目3個適應症處於NDA階段，10余個項目正處於臨床階段。公司成功構建了享譽國際的專有ADC及新型偶聯藥物平台OptiDC™，已有2個ADC項目5個適應症獲批上市，多個ADC或新型偶聯藥物產品處於臨床或臨床前研究階段。瞭解更多，請訪問：https://www.kelun-biotech.com/。 

During the current earnings season, suppliers with exposure to Apple Inc. (AAPL.US) and the high-end segment demonstrated relatively stronger resilience, while low-end and mid-range Android smartphones were hit hard by rising component prices, UOB Kay Hian said in a report.

The broker expected the pressure to persist through 2027 and preferred Apple supply chain stocks over Android supply chain names, given their more resilient shipments, margins and ASP.

The broker was also bullish on manufacturers that have meaningfully diversified into AI devices and AI servers, citing these businesses' meaningful buffer. The broker maintained an Overweight rating on the sector and preferred AI hardware over handset supply chain stocks.

SUNNY OPTICAL (02382.HK), Q TECH (01478.HK) and AAC TECH (02018.HK) were all expected to chart high double-digit growth in related businesses in 2026. AI infrastructure components were estimated to begin ramping up from 2H26.

The broker's ratings and target prices for Apple supply chain stocks and AI hardware stocks are listed below:

Stock|Rating|TP
SUNNY OPTICAL (02382.HK)|Buy|HKD106
XIAOMI-W (01810.HK)|Hold|HKD26.2
AAC TECH (02018.HK)|Buy|HKD47.8
Q TECH (01478.HK)|Hold|HKD6.7
BYD ELECTRONIC (00285.HK)|Sell|HKD14.5
COWELL (01415.HK)|Buy|HKD48
LENS (06613.HK)|Buy|HKD43.1
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Tesla, Inc. (TSLA.US) CEO Elon Musk said the company will unveil the long-delayed next-generation Roadster electric sports car on October 1, nearly a decade after the previous-generation Roadster.

The next-generation Roadster will reportedly feature a redesigned model, and a limited-edition version developed in collaboration with SpaceX (SPCX.US), equipped with "cold gas thrusters", may also be announced at the launch event.
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Anthropic is in talks to bring in NVIDIA Corporation (NVDA.US) as a cornerstone investor, with the latter considering an investment of up to USD10 billion, Reuters, citing sources, reported.

Anthropic is reportedly seeking to raise USD100 billion in the IPO, with a valuation that could reach about USD2 trillion. Bringing in NVIDIA as a cornerstone investor may strengthen investor confidence in the listing.
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Apple's iPhone 18 Pro series officially kicked off pre-orders on Saturday (12th). During Saturday and Sunday (13th), police received reports from more than 700 people alleging that their credit cards were suspected to have been fraudulently used to purchase phones online, involving around HKD14.7 million. The largest single case involved about HKD114,000. No arrests have been made so far.

A spokesperson for the Hong Kong Monetary Authority said credit card transactions have always required effective measures to ensure security and protect customer interests. Individual merchants may choose not to use or may suspend additional authentication arrangements, such as in-app authentication or one-time passwords, due to operational considerations. In such cases, merchants must bear responsibility and financial losses arising from unauthorized transactions.

The spokesperson emphasized that cardholders should carefully check transaction records. If they suspect or discover unauthorized use of their credit cards, they should notify the card-issuing bank as soon as possible, including immediately disabling the relevant credit card through online banking services. Generally, if a bank credit card account is used for unauthorized transactions and the cardholder has not committed fraud or gross negligence, the cardholder will not be liable for the unauthorized transactions.

An HSBC spokesperson said the bank had noted online discussions indicating that customers of different banks suspected their credit cards had been fraudulently used to order mobile phones. The bank will investigate for customers and, where applicable, initiate chargeback mechanisms according to credit card organization rules.

BOC Hong Kong reminded customers to immediately log into mobile banking to block the relevant credit card if they discover unauthorized transactions. The bank said its credit card customers are protected by refund mechanisms, and customers will not be liable for any verified unauthorized credit card transactions.

A Standard Chartered spokesperson said customers who discover any unauthorized transactions should notify the bank and report the case to police as soon as possible. Customers may also instantly block their credit cards through online banking or SC Mobile. The bank will immediately investigate and follow up according to established procedures and, where applicable, submit refund applications to relevant credit card organizations. If investigations confirm that the transactions were unauthorized by the cardholder, the cardholder will not be responsible for the related payments.

A Hang Seng Bank spokesperson said customers who discover suspicious credit card transactions should immediately freeze their credit cards through the Hang Seng Bank mobile application or contact the bank. During the investigation period, Hang Seng will support affected customers and, where applicable, initiate chargeback mechanisms according to credit card organization rules. The bank reiterated that if customers have used their credit cards reasonably and prudently, the bank will provide full assistance in completing refund procedures.
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SHANGHAI, Sept. 14, 2026 /PRNewswire/ -- Shanghai Electric (SEHK: 02727, SSE: 601727) has achieved a milestone in the high-end overseas energy sector by securing the contract for Unit 3 of the Sarawak Samalaju Combined Cycle Gas Turbine (CCGT) Project in Malaysia. The win represents significant international recognition of Shanghai Electric's heavy-duty gas turbine technology, underscoring the company's growing competitiveness in the global gas turbine market.

Under the agreement, Shanghai Electric will deliver a full EPC turnkey solution for the gas-fired power plant, coupled with a 25-year long-term service agreement (LTSA) covering all major equipment. Notably, every core component—from gas turbines and steam turbines to generators, heat recovery steam generators, and air-cooled systems—will be manufactured in-house by Shanghai Electric, which will also serve as the sole provider of the long-term maintenance and service program. This integrated, end-to-end capability gives Shanghai Electric full life-cycle coverage, spanning equipment manufacturing, systems integration, and multi-decade operational support—a vertical model that brings the company on par with the established global leaders in the heavy-duty gas turbine sector.

Shanghai Electric's current heavy-duty gas turbine lineup features two principal models, with output ratings of 300 MW and 78 MW, respectively. To date, the company has delivered 103 units, with total installed capacity from commissioned projects exceeding 21,000 MW. The units covered by Shanghai Electric's long-term service and maintenance programs have accumulated more than 1.3 million operating hours. With robust production capacity available across both turbine classes, Shanghai Electric is positioned to offer new units for delivery as early as 2028. Beyond the Malaysian energy developer that awarded the current contract, project developers in Indonesia, Thailand, the Philippines, and Vietnam have also expressed strong interest in placing orders.

HONG KONG, Sept. 13, 2026 /PRNewswire/ -- Akeso, Inc. (9926.HK) today announced the presentation of positive overall survival (OS) results from the randomized, double-blind, multicenter, registrational Phase III HARMONi-2 study (AK112-303) at the 2026 World Conference on Lung Cancer (WCLC), organized by the International Association for the Study of Lung Cancer (IASLC). The study evaluated the company's first-in-class next-generation immuno-oncology therapy, ivonescimab, versus pembrolizumab as first-line treatment for patients with PD-L1-positive (PD-L1 TPS ≥1%) locally advanced or metastatic non-small cell lung cancer (NSCLC).

The findings were selected as a Late-Breaking Abstract (LBA) for oral presentation and included in the official WCLC press program.

On September 13, the WCLC official website published the Abstract data on overall survival (OS) from the HARMONi-2 study. On September 15, Professor Caicun Zhou, Principal Investigator of HARMONi-2, IASLC President, and Director of the Department of Oncology at Shanghai East Hospital, will deliver the formal oral presentation (Oral) at the conference, sharing the complete results of the HARMONi-2 study with the global industry.

As of the data cutoff on August 20, 2026, the median follow-up was 36 months, and a total of 234 overall survival (OS) events had occurred. For this OS analysis, a prespecified O'Brien-Fleming spending function was used, with a one-sided alpha of 0.0141.

Results showed that, compared with pembrolizumab, first-line treatment with ivonescimab significantly prolonged OS in patients with PD-L1-positive advanced NSCLC.  This finding met the prespecified statistical significance threshold and demonstrated clear clinical benefit. The overall survival benefit was generally consistent across prespecified subgroups, with particularly pronounced benefit observed in the PD-L1-high population.

1. Intention-to-Treat (ITT) Population: Median OS of 30.8 Months with Ivonescimab, 27% Reduction in Risk of Death

• In the ITT population, ivonescimab monotherapy significantly prolonged OS versus pembrolizumab, with median OS of 30.8 months versus 22.6 months (HR=0.73; 95% CI: 0.57–0.95; P=0.009), corresponding to a 27% reduction in the risk of death.

2. Overcoming Traditional Anti-VEGF Treatment Contraindications: No Significant Increase in Bleeding Risk Observed in High-Risk Squamous Patients

Squamous NSCLC patients accounted for 45.5% of the HARMONi-2 population, and non-squamous patients for 54.5%. Among squamous patients treated with ivonescimab, 72.2% had central tumors, 10.0% had tumor cavitation or necrosis, and 6.7% had tumors encasing major vessels.

These populations are traditionally considered contraindicated or high-risk for anti-VEGF therapies and have long lacked effective treatment options. However, no apparent increase in bleeding risk was observed with ivonescimab, and these patients showed favorable benefit.

3. Consistent OS Benefit with Ivonescimab Regardless of PD-L1 Expression Level, with Particularly Pronounced Benefit in the TPS ≥50% Population

• In the PD-L1 TPS ≥50% subgroup, OS HR=0.58 (95% CI: 0.38–0.89), corresponding to a 42% reduction in the risk of death.
• In the PD-L1 TPS 1–49% subgroup, OS HR=0.85 (95% CI: 0.61–1.18), corresponding to a 15% relative reduction in the risk of death.

4. Consistent OS Benefit with Ivonescimab Regardless of Histology (Squamous and Non-Squamous)

• In the squamous cell carcinoma subgroup, OS HR=0.65 (95% CI: 0.45–0.95), corresponding to a 35% reduction in the risk of death.
• In the non-squamous subgroup, OS HR=0.79 (95% CI: 0.55–1.14), corresponding to a 21% reduction in the risk of death.

5. Favorable Overall Safety Profile with No New Safety Signals; Safety Characteristics Generally Consistent Between Arms

In May 2024, a prespecified interim analysis of progression-free survival (PFS) assessed by the Independent Data Monitoring Committee (IDMC) confirmed that HARMONi-2 met its primary PFS endpoint with statistically significant and clinically meaningful results. Median PFS was 11.14 months with ivonescimab versus 5.82 months with pembrolizumab (HR=0.51, P<0.0001). This indication was approved in China in 2025.

HARMONi-2 is the first randomized, double-blind, controlled Phase III clinical study to demonstrate statistically significant positive OS and PFS results versus pembrolizumab.

An international multicenter Phase III clinical study evaluating ivonescimab monotherapy versus pembrolizumab as first-line treatment for PD-L1-high NSCLC (HARMONi-7/AK112-3007) is currently progressing efficiently.

To date, ivonescimab has consistently achieved dual-positive OS and PFS results across multiple Phase III head-to-head trials against PD-1/L1 therapies and continues to expand into major solid tumors beyond lung cancer. The synergistic antitumor effects of ivonescimab's dual "immuno-oncology + anti-angiogenesis" mechanism continue to be validated in both clinical research and real-world settings. Ivonescimab has the potential to provide a more effective treatment option with a manageable safety profile for cancer patients worldwide and to drive continued progress in oncology care.

About Akeso

Akeso (HKEX: 9926.HK) is a leading biopharmaceutical company committed to the research, development, manufacturing and commercialization of the world's first or best-in-class innovative biological medicines. Founded in 2012, Akeso has built a comprehensive R&D innovation ecosystem anchored by its proprietary Tetrabody antibody technology platform, AI-powered drug R&D platform, Dual-Shield ADC technology platform, Dual-Lock T-cell engager (TCE) technology platform, Tissue-Smart siRNA/mRNA technology platform, and cell therapy technology platforms.

Backed by world-class GMP manufacturing facilities and a highly efficient, integrated commercialization system, Akeso has developed into a globally competitive biopharmaceutical enterprise. Leveraging its fully integrated, multi-functional platform, the company maintains a robust pipeline of more than 50 innovative assets targeting cancer, autoimmune diseases, inflammation, metabolic disorders, and other major therapeutic areas. Of these, nearly 30 candidates have advanced into clinical trials, including 15 bispecific or multispecific antibodies and bispecific ADCs. Eight innovative drugs are commercially available, and two additional drugs with three indications are currently under regulatory review for marketing approval.

Akeso is committed to becoming a global leader in biopharmaceuticals through efficient and breakthrough innovation in R&D, developing novel therapies that are first-in-class or best-in-class, and providing better disease solutions for patients around the world.

Forward-Looking Statements

This announcement by Akeso, Inc. (9926.HK, "Akeso") contains "forward-looking statements". These statements reflect the current beliefs and expectations of Akeso's management and are subject to significant risks and uncertainties. These statements are not intended to form the basis of any investment decision or any decision to purchase securities of Akeso. There can be no assurance that the drug candidate(s) indicated in this announcement or Akeso's other pipeline candidates will obtain the required regulatory approvals or achieve commercial success. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.

Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the P.R. China, the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; Akeso's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the Akeso's patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions.

Akeso does not undertake any obligation to publicly revise these forward-looking statements to reflect events or circumstances after the date hereof, except as required by law.

OpenAI's GPT-6 Astra marks a new phase for frontier AI, demonstrating leading capabilities in computer usage, scientific research and professional work, CLSA said in a research report. Beyond improvements in benchmark testing, the shortening model iteration cycle is increasing the importance of product experience and brand premium.

Meanwhile, rising training compute demand is reinforcing the scale advantages of leading frontier laboratories. In the broker's view, these trends will expand the AI total addressable market and accelerate progress toward more autonomous research systems and ultimately artificial superintelligence (ASI).

Training compute intensity has once again become an investor focus. NVIDIA Corporation (NVDA.US) founder and CEO Jensen Huang disclosed that Astra was trained using more than 100,000 Grace Blackwell chips, while the next-generation training cluster accelerator could exceed 400,000 units, highlighting the capital-intensive nature of frontier AI.

Based on the broker's estimates, calculated by revenue relative to inference and training compute costs, Anthropic's compute multiple will reach 1.8x in 2Q26 and the company has already achieved profitability, leading globally, while Chinese peers are at around 0.4x.

US peers have already entered competition involving more than 10 trillion parameters, while Chinese laboratories remain at the 3 trillion parameter level. The key challenge in narrowing the capability gap lies in compute supply constraints, partially offset by greater emphasis on post-training, infrastructure efficiency and test-time compute.
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