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2026-03-31
17:40
Ivonescimab Shows Quality of Life Benefits in Chemotherapy-Free First-Line NSCLC: Health-Related Quality of Life Data from the HARMONi-2 Study Presented at ELCC 2026

HONG KONG, March 31, 2026 /PRNewswire/ -- Akeso, Inc. (9926.HK)  ("Akeso" or the "Company") announced the results of health-related quality of life (HRQoL) data (Poster: 107P) from the HARMONi-2 study at the 2026 European Lung Cancer Congress (ELCC). The study evaluated ivonescimab, the company's first-in-class PD-1/VEGF bispecific antibody, versus pembrolizumab as a first-line treatment for patients with PD-L1–positive non-small cell lung cancer (NSCLC).

In the primary analyses of HARMONi-2, ivonescimab demonstrated a median progression-free survival (PFS) of 11.14 months compared with 5.82 months for pembrolizumab (HR = 0.51; P < 0.0001), representing a 49% reduction in the risk of disease progression or death, with a manageable safety profile. The exploratory analysis presented at ELCC 2026 focuses on the other key pillar of treatment evaluation: HRQoL. The HRQoL analysis was conducted with the QLQ-C30, QLQ-LC13, and EQ-5D-5L instruments, showed that in the chemotherapy-free setting, ivonescimab not only significantly extended PFS but also delivered meaningful improvements in health-related quality of life. These findings provide additional, robust evidence to support the broad clinical use of ivonescimab and reinforce its role as a new standard of care (SOC) in first-line lung cancer treatment.

Key Findings:

Global health and functional status with sustained improvements and delayed deterioration:

In the primary analysis of HARMONi-2,  in the ivonescimab group, the median time to deterioration (TTD) in global health status/quality of life (GHS/QoL) was not reached (vs 9.9 months for pembrolizumab), and the 12-month deterioration-free rate was 51% (vs 46%). The results published at ELCC2026, scores for GHS/QoL, physical function, and emotional function improved from baseline in both arms. In the ivonescimab arm, the mean GHS/QoL score increased from 71.8 (SD 17.6) at baseline to 78.5 (SD 15.9) at week 12 and remained stable at 78.5 (SD 16.0) at week 30. In the pembrolizumab arm, the mean score improved from 73.6 (SD 17.5) at baseline to 76.7 (SD 16.6) at week 12 and decreased slightly to 76.5 (SD 16.9) by week 30.

Better control of key lung cancer symptoms, with a sustained advantage in dyspnea:

According to the EORTC QLQ-LC13 lung cancer-specific questionnaire, patients in the ivonescumab group experienced sustained reductions in scores for cough, hemoptysis, and dyspnea.

Cough: Median TTD was not reached; the mean score decreased from 29.9 (SD 23.3) at baseline to 19.0 (SD 18.2) at week 12 and 19.6 (SD 21.7) at week 30.

Hemoptysis: The mean score decreased from 7.2 (SD 14.6) at baseline to 2.9 (SD 9.5) at week 30.

Dyspnea: Ivonescumab showed a trend toward superior long-term control, with the mean score decreasing from 17.5 (SD 16.0) at baseline to 12.1 (SD 14.6) at week 30.

High and stable health utility values:

On the EQ-5D-5L visual analog scale (VAS), the mean health status score increased from 81.9 (SD 13.5) at baseline to 84.3 (SD 10.6) at week 12 and remained high at 83.7 (SD 11.4) at week 30. Health utility values, which reflect overall patient well-being, remained consistently high throughout ivonescimab treatment, with mean values of approximately 0.9 (SD 0.1) at baseline, week 12, and week 30.

Based on the HARMONi-2 results, ivonescimab became the first therapy to show a significant PFS benefit over pembrolizumab in a head-to-head Phase III study. Ivonescimab was approved in 2025 in China as a first-line treatment for patients with PD-L1-positive NSCLC, establishing a novel,  more effective, and safer chemotherapy-free option. To date, the breakthrough clinical value of ivonescimab has been demonstrated in dozens of clinical trials and real-world experience involving more than 70,000 patients.

About Akeso
Akeso (HKEX: 9926.HK) is a leading biopharmaceutical company committed to the research, development, manufacturing and commercialization of the world's first or best-in-class innovative biological medicines. Founded in 2012, the company has established a robust R&D innovation ecosystem centered on its Tetrabody antibody technology platform, AI-powered drug R&D platform, Dual-Shield ADC technology platform, Dual-Lock T-cell engager (TCE) technology platform, Tissue-Smart siRNA/mRNA technology platform, and cell therapy technology platforms. Supported by a global-standard GMP manufacturing infrastructure and a highly efficient, integrated commercialization model, the company has evolved into a globally competitive biopharmaceutical focused on innovative solutions. With fully integrated multi-functional platform, Akeso is internally working on a robust pipeline of over 50 innovative assets in the fields of cancer, autoimmune disease, inflammation, metabolic disease and other major diseases. Among them, 27 candidates have entered clinical trials (including 15 bispecific/multispecific antibodies and bispecific ADCs. Additionally, 7 new drugs are commercially available. Through efficient and breakthrough R&D innovation, Akeso always integrates superior global resources, develops the first-in-class and best-in-class new drugs, provides affordable therapeutic antibodies for patients worldwide, and continuously creates more commercial and social values to become a global leading biopharmaceutical enterprise.

Forward-Looking Statements

This announcement by Akeso, Inc. (9926.HK, "Akeso") contains "forward-looking statements". These statements reflect the current beliefs and expectations of Akeso's management and are subject to significant risks and uncertainties. These statements are not intended to form the basis of any investment decision or any decision to purchase securities of Akeso. There can be no assurance that the drug candidate(s) indicated in this announcement or Akeso's other pipeline candidates will obtain the required regulatory approvals or achieve commercial success. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.

Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in P.R.China, the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; Akeso's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the Akeso's patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions.

Akeso does not undertake any obligation to publicly revise these forward-looking statements to reflect events or circumstances after the date hereof, except as required by law.

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17:38
郭廣昌:復星國際每股NAV達港元18.1元,把資源聚焦到高增長核心賽道

香港2026年3月31日 /美通社/ -- 3月31日上午,復星國際董事長郭廣昌在復星國際2025年業績發佈會上表示,復星國際人民幣234億元的減值計提是「審慎的會計處理,不是經營出了問題」,這次減值是「晴天修屋頂」,管理層對未來發展有信心。

郭廣昌強調,從長遠來看,這次減值處理標誌着復星進入了全新發展階段。「我們堅決退出那些盈利不佳、價值不達標的資產,把資源聚焦到高增長的核心賽道,推動公司向更輕盈、更健康、更可持續的方向發展。」

他介紹,從復星各板塊的經營實績看,復星的核心產業經營穩健。醫藥板塊的全球化業務持續突破,多款產品在海外上市,也有多個有巨大潛力的在研管線;保險板塊境內外的業務都在增長,葡萄牙保險的業務拓展到拉美、非洲等區域,國內復星聯合健康、復星保德信人壽盈利大幅提升;旅文板塊的Club Med業績也創下了歷史新高。

「這些產業具備持續創造利潤和現金流的能力,是復星保持增長的底氣。這次大額減計後,未來的經營成果一定會更真實地體現復星核心產業的經營質量。我相信復星是有穿越週期的能力,短期內會有陣痛,但長遠來看,所做的這些都是為了復星走得更穩、走得更遠。」郭廣昌說。

他表示,復星管理層對公司未來的發展有確定性的預期,有充分信心。復星國際調整後淨資產價值(NAV)人民幣1,335億元,每股NAV達到港元18.1元。公司董事會已宣佈股份回購計劃,大股東和管理團隊也會進行增持。未來復星會結合經營改善和現金流狀況,積極研究並逐步推出更多回饋股東的舉措,包括優化分紅機制等等。

3月30日晚,復星國際公佈2025年業績。報告期內集團總收入達人民幣1,734.3億元,經調整產業運營利潤為人民幣40億元。四大核心子公司收入人民幣1,282億元,佔集團總收入的74%。其中,復星醫藥歸母淨利潤人民幣33.71億元,同比增長21.69%;復星葡萄牙保險歸母淨利潤達歐元2.01億元,同比增長15.8%。

和往年比較,復星整體業績數據保持穩健。不過這一年復星對部分存在減值跡象的地產項目及部分非核心業務板塊的商譽、無形資產進行了一次性非現金減值計提和價值重估,造成年度賬面虧損人民幣234億元,其中地產減值佔比為55%,非核心資產減值45%。

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17:36
Guo Guangchang: Fosun International's NAV reaches HKD18.1 Per Share, Focusing Resources on Core, High‑Growth Areas

HONG KONG, March 31, 2026 /PRNewswire/ -- On the morning of 31 March, Guo Guangchang, Chairman of Fosun International, stated at Fosun International's 2025 annual results presentation that the RMB23.4 billion impairment provision was a "prudent accounting measure, not a reflection of operational issues". He described the impairment as "repairing the roof on a sunny day" and said that the management is confident in Fosun's future development.

Guo Guangchang emphasized that, from a long-term perspective, this impairment marks Fosun's entry into a new stage of development. "We will resolutely divest assets with low profitability and value below target, and focus our resources on core, high‑growth areas, steering the Company toward a leaner, healthier, and more sustainable future."

He explained that the operating results of Fosun's various business segments indicate that Fosun's core businesses remain solid. The pharmaceutical business has continued to make breakthroughs in its global expansion, with multiple products launched overseas and several promising pipeline products. The insurance business saw growth both domestically and internationally, with Fosun Insurance Portugal expanding its business into regions such as Latin America and Africa. Meanwhile, domestic insurance companies, Fosun United Health Insurance and Pramerica Fosun Life Insurance, recorded significant profit increases. In the culture and tourism business, Club Med achieved record-high results.

"These businesses are capable of generating sustainable profit and cash flow, laying the foundation for Fosun's continued growth. Following this significant impairment, Fosun's future operating results will more accurately reflect the underlying quality of our core businesses. I believe Fosun has the ability to navigate through cycles. While we may face some short-term challenges, these efforts will position Fosun for steadier, longer-term growth," said Guo Guangchang.

He stated that Fosun's management has clear expectations and full confidence in the Company's future development. Fosun International's adjusted net asset value (NAV) was RMB133.5 billion, with a NAV per share reaching HKD18.1. The Company's Board of Directors has announced a share buyback program. Fosun's major shareholder and management team will also increase their holdings in the shares of the Company. In the future, Fosun will actively explore and gradually introduce further measures to reward shareholders, including optimizing the dividend mechanism, in line with operational improvements and cash flow conditions.

On the evening of 30 March, Fosun International announced its 2025 annual results. During the Reporting Period, the Group's total revenue reached RMB173.43 billion, and adjusted industrial operation profit was RMB4 billion. Its four core subsidiaries generated RMB128.2 billion in revenue, accounting for 74% of the Group's total revenue. Among them, Fosun Pharma achieved a net profit attributable to shareholders of the parent of RMB3.371 billion, representing a year-on-year increase of 21.69%. Fosun Insurance Portugal achieved a net profit attributable to owners of the parent of EUR201 million, up 15.8% year-on-year.

Compared to prior years, Fosun's results have largely remained stable. However, Fosun made non-cash impairment provisions and value revaluations on certain real estate projects with impairment indicators and goodwill and intangible assets of certain non-core business segments, resulting in a book loss of RMB23.4 billion in 2025, of which real estate-related impairment accounted for approximately 55%, while impairment of non-core assets accounted for approximately 45%.

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17:00
New Oriental to Report Third Quarter 2026 Financial Results on April 22, 2026

BEIJING, March 31, 2026 /PRNewswire/ -- New Oriental Education and Technology Group Inc. (the "Company" or "New Oriental") (NYSE: EDU/ 9901.SEHK), a provider of private educational services in China, today announced that it will report its financial results for the third quarter ended February 28, 2026, before the U.S. market opens on April 22, 2026. New Oriental's management will host an earnings conference call at 8 AM on April 22, 2026, U.S. Eastern Time (8 PM on April 22, 2026, Beijing/Hong Kong Time). Participants can join the conference using the below options:

Dialling-in to the conference call:

Please register in advance of the conference, using the link provided below. Upon registering, you will be provided with participant dial-in numbers, and unique personal PIN.

Conference call registration link:
https://register-conf.media-server.com/register/BI2d1b37f83b4645f08b73fdd17af502f3. It will automatically direct you to the registration page of "New Oriental FY2026 Q3 Earnings Conference Call" where you may fill in your details for RSVP.

In the 10 minutes prior to the call start time, you may use the conference access information (including dial in number(s) and personal PIN) provided in the confirmation email received at the point of registering.

Joining the conference call via a live webcast:

Additionally, a live and archived webcast of the conference call will be available at http://investor.neworiental.org.

Listening to the conference call replay:

A replay of the conference call may be accessed via the webcast on-demand by registering at https://edge.media-server.com/mmc/p/7x5ve8hp first. The replay will be available until April 22, 2027.

About New Oriental

New Oriental is a provider of private educational services in China offering a wide range of educational programs, services and products to a varied student population throughout China. New Oriental's program, service and product offerings mainly consist of educational services and test preparation courses, private label products and livestreaming e-commerce, overseas study consulting services, and educational materials and distribution. New Oriental is listed on NYSE (NYSE: EDU) and SEHK (9901.SEHK), respectively. New Oriental's ADSs, each of which represents ten common shares, are listed and traded on the NYSE. The Hong Kong-listed shares are fully fungible with the ADSs listed on NYSE.

For more information about New Oriental, please visit http://www.neworiental.org/english/.

Contacts

For investor and media inquiries, please contact:

In China:

Ms. Sisi Zhao                                                                     Ms. Rita Fong
New Oriental Education and Technology Group Inc.         FTI Consulting                      
Tel:         +86-10-6260-5568                                              Tel:        +852 3768 4548                   
Email:     [email protected]                                                 Email:    [email protected]

 

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14:36
Joyson Electronics posts FY2025 revenue of RMB 61.2 bln; profit attributable to shareholders jumps nearly 40% YoY

HONG KONG, March 31, 2026 /PRNewswire/ -- Joyson Electronics (0699.HK/600699.SH) announced its FY2025 annual results. Its total revenue for the year reached RMB 61.2 billion, while profit attributable to shareholders was approximately RMB 1.34 billion, representing an increase nearly 40% YoY. Fresh orders (including autonomous driving) topped RMB 97 billion, once again setting a record high.

The company said its cost-efficiency initiatives gained traction in FY2025, supporting improved profitability. Profit totaled RMB 2.2 billion approximately, while adjusted profit attributable to shareholders came in at RMB 1.5 billion. Gross margin increased to 18.3%, improving by 2.1 percentage points from a year earlier, supported by operational optimization in overseas markets.

Moreover, Joyson Electronics also reported new orders of RMB 97 billion for the year, citing breakthrough in autonomous driving and cockpit–driving integration. Its first L3 intelligent driving domain controller is slated to enter mass production next year, while the L4 product is expected to be deployed in low-speed unmanned logistics vehicles.

Joyson is advancing intelligent driving on a "multi-chip platform + ecosystem collaboration" roadmap—deepening partnerships with algorithm players including Momenta and SENIOR, iterating L3/L4 ADAS functions, and working with chipmakers such as Qualcomm, NVIDIA, Horizon Robotics and Black Sesame Technologies. Joyson has made a strategic investment in Xinxin Hangtu, thereby establishing a full-stack intelligent driving solution spanning from entry-level to high-end offerings, and further extending its capabilities towards fully autonomous driving.

Looking ahead, the company said it expects further progress in L3/L4 intelligent driving in FY2026.

FY2025, Joyson invested around RMB 4.42 billion to accelerate R&D in new technologies, leveraging its automotive strengths to expand into next-generation agents, optical communications, and the server power infrastructure as new growth engines.

Meanwhile, Joyson Electronics is actively building positions in optical communications and server power, including the launch of an in-vehicle optical module co-developed with Zhongji InnoLight, a strategic investment in Fast Photonics to advance optical-module commercialization globally, and develop optical module manufacturing capacity in North America. Moreover, Joyson has developed server power solutions leveraging its automotive-grade technologies and capabilities.

The Company said that, leveraging the "One Joyson" global platform and its first-mover advantages of "China efficiency" and a global footprint, it is well positioned to support Chinese domestic brands in accelerating their overseas expansion, and to capitalize on incremental opportunities arising from the intelligent-vehicle upgrade in overseas markets.

About Joyson Electronics

Joyson Electronics (600699.SH / 0699.HK) is an intelligent automotive technology solution provider, offering advanced products and solutions across the auto electronics, auto safety, and next-generation agents. It has over 25 R&D centers and 60 production bases worldwide, serving more than 100 auto brands as customers.

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10:51
New Nasdaq-100 Index Mechanism to Allow Entry for New Stocks as Early as 15th Day of Listing

Nasdaq (NDAQ.US) is set to introduce new rules to, among others, speed up the inclusion of newly listed large companies into its Nasdaq-100 Index.

Cameron Lilja, Nasdaq's global head of index solutions, told Reuters that the company is reforming the rules to ensure that newly listed large companies and those transferring boards can join the Nasdaq-100 Index without a prolonged waiting period.

These new rules will take effect on May 1, but changes in the index components are expected to occur in June. The new rules include a fast-track inclusion mechanism, under which Nasdaq will rank the market cap of new stocks on the 7th trading day and assess whether these new stocks are among the top 40 index components for potential eligibility.

If a new stock meets all eligibility criteria, it will be fast-tracked into the Nasdaq-100 Index after the 15th trading day.
~



AAStocks Financial News
Web Site: www.aastocks.com

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08:00
Innovent's Partner Ollin Biosciences Announces Final Data from Randomized Head-to-Head Study of IBI324 Compared to Faricimab (Vabysmo) in Wet Age-Related Macular Degeneration and Diabetic Macular Edema

  • OLN324 demonstrated meaningfully faster and greater improvements in anatomic outcomes in DME and numerically greater vision gains sustained through 20 weeks with fewer retreatments as compared to faricimab
  • New anatomic data demonstrates OLN324 achieves faster, greater, and more durable reductions in wAMD pigment epithelial detachment (PED) thickness versus faricimab
  • Ollin and Innovent Biologics advancing OLN324 into global Phase 3 studies in DME and wAMD in 2026

SAN FRANCISCO and SUZHOU, China, March 31, 2026 /PRNewswire/ -- Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures, and commercializes high-quality medicines for the treatment of oncology, autoimmune, cardiovascular and metabolic, ophthalmology and other major disease areas, today announced that the company's partner Ollin reported final, 20-week study completion data from its randomized, head-to-head Phase 1b JADE clinical study comparing OLN324(Innovent R&D code IBI324) , a higher-potency, smaller-format, higher-molar dose VEGF/Ang2 bispecific antibody, to faricimab (Vabysmo®), in patients with diabetic macular edema (DME) or wet (neovascular) age-related macular degeneration (wAMD). Final results released include favorable durability data for OLN324 compared to faricimab and new anatomic data showing faster, greater, and more durable control of wAMD pigment epithelial detachments (PEDs) with OLN324.

Topline data from the Week 12 primary endpoint readout, previously announced in January 2026 and presented at the Angiogenesis, Exudation, and Degeneration Symposium in February 2026, demonstrated OLN324, compared to faricimab, delivered superior anatomic outcomes in DME, including faster and greater retinal drying and more patients achieving absence of DME; equivalent retinal drying compared to faricimab in wAMD; rapid and sustained gains in vision in both DME and wAMD that were numerically better than faricimab; and had a favorable safety profile with no cases of intraocular inflammation. 

Final 20-Week Study Completion Data Highlights

The JADE trial, which enrolled 164 U.S. patients with either DME or wAMD, all patients initially received three monthly doses of OLN324 or faricimab. Thereafter, they were followed for an additional 12 weeks off treatment, during which they could be retreated based on protocol-specified criteria for disease recurrence that were the same for all groups.

At the final study visit at Week 20, 12 weeks after the last mandatory dose, DME patients treated with OLN324 continued to demonstrate greater retinal drying compared to those treated with faricimab, measured as mean change in central subfield thickness on optical coherence tomography, along with sustained vision gains that were numerically greater for OLN324 4 mg.

These improved efficacy outcomes were achieved with fewer retreatments compared to faricimab. 93% of DME patients randomized to OLN324 4 mg completed 12 weeks of follow-up without retreatment, versus 89% of patients randomized to faricimab.

In wAMD, the rapid and comparable improvements in retinal drying (mean change in OCT CST) observed from Day 1 to Week 12 with OLN324 and faricimab were sustained through Week 20. Patients treated with OLN324 experienced numerically greater vision gains than patients treated with faricimab; the BCVA improvements continued to separate between groups from Weeks 12 to 20, with a mean +2.2 letter advantage observed over faricimab for OLN324 4 mg at Week 20.

82% of OLN324 4 mg patients completed 12 weeks of follow-up without retreatment, compared with 81% of faricimab patients.

OLN324 continued to demonstrate a favorable safety profile, with zero cases of intraocular inflammation observed through the entirety of the study, compared with one case in a faricimab-treated patient. There were no cases of retinal vasculitis or occlusive retinal vasculitis with OLN324.

"These new JADE study data further strengthen the differentiated profile of OLN324, highlighting its robust anatomic efficacy and durability across both DME and wAMD. Combined with a favorable safety profile, these results underscore OLN324's potential to become a first-line treatment option for these vision-threatening diseases," said Jason Ehrlich, M.D., Ph.D., Co-founder and Chief Executive Officer of Ollin Biosciences. "We look forward to advancing OLN324 into global Phase 3 studies in both DME and wAMD later this year. Subject to regulatory communications, we expect the Phase 3 studies to recruit patients from North America, South America, Europe and Japan, and we are actively planning, in partnership with Innovent Biologics, to include China and South Korea."

"We are pleased to see that the latest 20-week data for OLN324 (IBI324) further highlight its differentiated profile and clinical potential," said Dr. Lei Qian, M.D., Ph.D., Chief R&D Officer of General Biomedicine at Innovent Biologics. "We look forward to continuing our close collaboration with Ollin and, following discussions with regulatory authorities, to accelerate the global Phase 3 clinical development of this best-in-disease therapy for retinal diseases."

New Anatomic Results on Pigment Epithelial Detachment (PED) Flattening Highlight Potential for Smaller-Format, Higher-Potency OLN324 to Improve Treatment of wAMD

In newly-available, pre-specified data, wAMD patients in the JADE trial randomized to OLN324 4 mg experienced faster and approximately 50% greater reductions in PED thickness at Week 12 compared to patients randomized to faricimab, measured as mean change in neovascular lesion complex thickness on optical coherence tomography (OCT). Through Week 20, in the off-treatment follow-up period, these improvements were more durable for patients randomized to OLN324 4 mg than faricimab.

"As a field, we've been looking for meaningful advancements that further improve anatomic outcomes in wAMD," said David Eichenbaum, M.D., FASRS, Director of Research, Retina Vitreous Associates of Florida. "These data suggest that OLN324's more potent Ang2 inhibition and smaller molecular format may translate into breaking through the efficacy ceiling experienced with current treatments and offering a clinically-relevant benefit in PED improvement – the most difficult to treat component of wAMD."

Retinal fluid (intraretinal and subretinal) and PEDs are two hallmark anatomic features of wAMD. PEDs are present in approximately 80% of wAMD patients. Persistent PEDs following anti-VEGF treatment are associated with development of subretinal fibrosis, an important cause of late vision loss in wAMD.

Full details of the final JADE study data are expected to be presented at upcoming medical and scientific conferences.

About the OLN324 JADE Study

JADE is a randomized, head-to-head Phase 1b clinical study comparing OLN324, a next-generation VEGF/Ang2 bispecific antibody, to faricimab (Vabysmo®), in patients with diabetic macular edema (DME) or wet (neovascular) age-related macular degeneration (wAMD). More than 160 patients with wAMD or DME were enrolled at sites in the United States. All patients initially received three monthly doses of either OLN324 2 mg, OLN324 4 mg, or faricimab 6 mg. Patients were evaluated at Weeks 1, 4, 8, 12, 16, and 20 and could be retreated at Weeks 12 or 16 based on protocol-specified retreatment criteria that were the same for all groups. The primary objective was to assess safety and tolerability (through Week 12 and Week 20). Prespecified exploratory efficacy objectives included the evaluation of OLN324 vs faricimab on visual acuity and various retinal anatomic parameters.

About OLN324

Building on the clinical success of intravitreal VEGF/Ang2 inhibition, OLN324 is a next-generation VEGF/Ang2 bispecific antibody engineered with substantially higher Ang2 potency relative to faricimab, increased molar dosing relative to both faricimab and aflibercept (including Eylea HD®), and a smaller protein format. VEGF and Ang2 are central drivers of retinal vascular diseases such as diabetic macular edema (DME) and wet (neovascular) age-related macular degeneration (wAMD), with Ang2 playing a key role in vascular instability, leakage, inflammation, and fibrosis. OLN324 was discovered by and is being developed in collaboration with Innovent Biologics (HKEX: 01801; Innovent R&D code: IBI324).

About Diabetic Macular Edema (DME)

Diabetic macular edema, a vision-threatening complication of diabetic eye disease, is a leading cause of vision loss among working-age adults in the developed world. In diabetic macular edema, progressive microvasculature damage, ischemia and microvascular inflammation result in vascular leakage and retinal swelling that compromise vision.

About Wet Age-Related Macular Degeneration (wAMD)

Age-Related Macular Degeneration, a chronic and progressive retinal disease, is the leading cause of vision loss among older adults in the developed world. In wet (or neovascular) AMD, abnormal blood vessels growing beneath the retina leak and bleed, resulting in significant vision impairment.

About Ollin Biosciences

Established in 2023, Ollin BiosciencesTM is a clinical-stage biopharmaceutical company dedicated to acquiring and developing best-in-disease therapies for vision-threatening diseases. With a differentiated pipeline, world-class team, and strong investor syndicate, Ollin is redefining what's possible in ophthalmology. For more information, please visit us at www.ollin.bio and follow us on LinkedIn and X.

About Innovent

Innovent is a leading biopharmaceutical company founded in 2011 with the mission to empower patients worldwide with affordable, high-quality biopharmaceuticals. The company discovers, develops, manufactures and commercializes innovative medicines that target some of the most intractable diseases. Its pioneering therapies treat cancer, cardiovascular and metabolic, autoimmune and eye diseases. Innovent has launched 18 products in the market. It has 4 assets in Phase 3 or pivotal clinical trials and 15 more molecules in early clinical stage. Innovent partners with over 30 global healthcare companies, including Lilly, Sanofi, Incyte, LG Chem and MD Anderson Cancer Center.

Guided by the motto, "Start with Integrity, Succeed through Action" Innovent maintains the highest standard of industry practices and works collaboratively to advance the biopharmaceutical industry so that first-rate pharmaceutical drugs can become widely accessible. For more information, visit www.innoventbio.com, or follow Innovent on Facebook and LinkedIn.

Disclaimer: Innovent does not recommend any off-label usage.

Vabysmo® is a registered trademark of Genentech, Inc.; Eylea® and Eylea HD® are registered trademarks of Regeneron Pharmaceuticals, Inc.

Forward-looking statement

This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words "anticipate", "believe", "estimate", "expect", "intend" and similar expressions, as they relate to Innovent Biologics ("Innovent"), are intended to identify certain of such forward-looking statements. The Company does not intend to update these forward-looking statements regularly.

These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of the Company with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond the Company's control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, the Company's competitive environment and political, economic, legal and social conditions.

The Company, the Directors and the employees of the Company assume (a) no obligation to correct or update the forward-looking statements contained in this site; and (b) no liability in the event that any of the forward-looking statements does not materialise or turn out to be incorrect.

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04:00
Nasdaq Leads Decline w/ 153-Pt Loss at Close; Oil Prices Higher; Memory Stocks Slide

Nasdaq led the decline on Monday as tech stocks plummeted owing to further spikes in oil prices, while the market neglected Federal Reserve Chairman Jerome Powell's comments on inflation stabilizing.

The Nasdaq sank 153 points or 0.7% to close at 20,794. The S&P 500 finished down 25 points or 0.4% at 6,343. The DJIA edged up by 49 points or 0.1% to end at 45,216.

Iran slapped transit fees on the Strait of Hormuz and banned US and Israeli vessels from passing through, causing New York oil futures to surpass USD100 for the first time since the conflict began.

Major techs wiped off early gains and turned south, with memory stocks leading the downfall. Micron (MU.US) slid 10%. Sandisk (SNDK.US) and Western Digital (WDC.US) also dived 7% and nearly 9%, respectively.

NVIDIA (NVDA.US) and Apple (AAPL.US) each fell about 1%. However, Meta (META.US) leaped 2% against the market.
~



AASTOCKS Financial News
Website: www.aastocks.com

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2026-03-30
23:29
Guo Guangchang's Letter to Shareholders: "Repair the Roof While the Sun Is Shining" -- Fosun Aims to Go Further with Greater Stability

HONG KONG, March 30, 2026 /PRNewswire/ -- Guo Guangchang, Chairman of Fosun International Limited (HKEX: 0656), issued a letter to its shareholders today, outlining the Company's strategic direction, accomplishments, and future plans. 

Dear shareholders,

Today, I would like to have an open and honest conversation with our shareholders, reflecting on Fosun's journey in 2025, sharing our thoughts, and outlining where we are heading next.

In 2025, the Company recorded a loss attributable to owners of the parent of RMB 23.4 billion. It should be noted that this loss does not reflect a deterioration in the Company's operating fundamentals. Instead, it was primarily attributable to the Board's prudent decision to recognize non-cash impairment provisions on certain projects arising from the Company's past development; it also involved impairment provisions on goodwill and intangible assets of certain non-core business segments. These provisions will not affect the Company's day-to-day operations, cash flow or business activities. Our core businesses such as pharmaceuticals and insurance continue to demonstrate steady growth.

A loss is never desirable. Such a result is also unprecedented in Fosun's more than thirty years of development. Although the loss is mainly non-cash items, we missed our profit expectations. As the Company's Chairman and Founder, I would like to express my sincere apologies to all shareholders and partners who care about Fosun's development. Over the years, Fosun has been bold in exploring and experimenting. We have had our share of successes and some missteps, each coming with valuable lessons learned. In recent years, China's real estate industry has undergone macro-structural adjustments. Although real estate accounts for a small portion of Fosun's business, it is natural for the market and investors to ask: Have Fosun's real estate projects not faced challenges and pressures, have all our past investments performed without setbacks? Of course, the answer is no. In hindsight, under the current market conditions, some of the projects we invested in years ago are now valued differently from what we expected at the time of investment. Accordingly, the Board has taken a prudent decision to complete this asset impairment, allowing Fosun to focus its resources and efforts more effectively on core, high‑growth areas. At a time when the global economy is generating opportunities amid volatility and China's innovation-driven industries are gaining growth momentum, deepening our strategic focus now allows us to optimize our asset structure and helps us secure a stronger position in key sectors, positioning Fosun as a leaner, healthier, and more sustainable company.

In terms of operating fundamentals, Fosun recorded operating revenue of RMB173.4 billion in 2025, with overseas revenue accounting for 54.7% of the total. Net cash flow from operating activities remained positive, average cost of debt continued to improve, and credit rating agencies such as S&P maintained stable ratings. Meanwhile, our financing capacity remained strong and our funding channels open. Our high-quality and resilient assets position us well for future growth. The total revenue of the four core enterprises - Fosun Pharma, Yuyuan, Fosun Portugal Insurance and FTG - reached RMB 128.2 billion, accounting for 74% of the Group's total revenue, a year-on-year increase of 3 percentage points.

It is precisely this strong foundation, together with the continued support of our partners, that gives us the confidence and determination to "repairing the roof on a sunny day". This is the moment to shed historical burdens and pursue predictable, sustainable growth. We must strengthen our core businesses with greater focus and depth to achieve steadier, longer-term growth in the next phase.

Smart innovation and integrated innovation driven by innovation

Going global or going obsolete. Innovation works the same way. Innovate or be left behind. In this fast-paced era, we must remain committed to innovation, especially smart innovation. We must collaborate with others and learn from others. Innovation is not a solo endeavor, nor should it happen behind closed doors. That is why I have always emphasized "integrated innovation", building an innovation system with two core capabilities, "global research and development ("R&D") + global business development ("BD")".

In 2026, we will place even greater emphasis on innovation as our top priority, steering Fosun's transition from scale expansion toward quality enhancement, and from resource integration toward value creation.

We have always been committed to pharmaceutical innovation. As early as 2006, we began systematically building our pharmaceutical R&D capabilities, starting with high-value generic drugs and steadily advancing toward true innovation. In 2019, China's first biosimilar, HANLIKANG, received marketing approval, marking a major milestone. By 2023, Henlius had turned profitable, 17 years since we first embarked on this journey. Throughout the years, we have remained true to our original aspiration of "always striving to heal", and to our vision of helping people live to 121.

Looking back, we now have nearly 70 major pipeline projects on innovative drugs (calculated by indications), forming a tiered pipeline spanning "early-stage frontier research, mid-stage proof-of-concept, and late-stage clinical expansion". By continuously strengthening our innovation pipeline, we are accelerating the clinical translation and commercialization of innovative technologies and products. We currently have multiple blockbuster candidates in the pipeline.

Take Henlius as an example. It has already achieved dual-engine growth driven by both biosimilars and innovative drugs. Core products like HANLIKANG, HANQUYOU, and HANSIZHUANG have been approved for marketing in around 60 countries and regions worldwide. HANSIZHUANG has not only been launched in Europe, but has also been included in public reimbursement programs in seven countries, including Germany, Italy, and Spain. Fosun Pharma has progressively established a high-value pipeline portfolio focusing on core therapeutic areas including oncology (solid tumors, hematologic tumors), immunology, inflammation and neurodegenerative diseases. Moving forward, Fosun Pharma will continue to strengthen its core technology platforms encompassing antibodies, antibody-drug conjugate ("ADC"), small molecules and cell therapy, while actively expanding its presence in cutting-edge technologies such as radiopharmaceuticals and small nucleic acids, enhancing our R&D ecosystem. We are currently planning the spin-off and separate listing in Hong Kong for our vaccine platform, Fosun Adgenvax, aiming to leverage the capital market to improve its governance standards and sustainable development capabilities, thereby creating greater value for our shareholders.

In terms of artificial intelligence ("AI"), I have been following it closely over the past few years. However, we are not chasing the concept of large language models. For us, AI is not about appearances; it is about solving real problems. And we have already made tangible progress. Fosun Pharma's PharmAID® Pharmaceutical Intelligence Platform now delivers T+1 data updates, accelerating drug R&D; FTG's AI G.O intelligent system makes tourism services more personalized. More importantly, AI is now deeply integrated into Fosun's daily operations to enhance decision-making efficiency and optimize operating costs. Going forward, we will continue to invest in AI to make it a truly practical operational tool, maximizing efficiency across the Group.

Fosun always embraces ecosystem thinking. We believe innovation thrives through collaboration, not solo efforts. Take Fosun United Health Insurance's "Ruixingbao" as an example: through our "insurance + industry" model, we integrate insurance services with premier medical resources such as Ruijin Hospital, along with pharmaceutical, healthcare, and consumer offerings. This makes insurance the connector, linking our ecosystem to families and turning ecosystem advantages into product competitiveness. Looking ahead, we will launch more products that bring together ecosystem resources to meet the needs of customers and serve more families. This is where our deepest sense of fulfillment comes from.

Innovation keeps us young. Fosun was founded 34 years ago, but we still approach every day as if it were day one, with a constant hunger for new technologies, new opportunities, and new possibilities.

Deepening global operations: from business presence to product and brand globalization

Fosun's globalization journey began in 2007 with our listing on the Hong Kong Stock Exchange. At that time, we started building our overseas business presence through equity and debt investments. Over the years, our globalization journey has evolved through three phases: from "China Expertise + Global Capability", to "Combining China's Growth Momentum with Global Resources" and then to "Combining Global Resources with China's Capabilities". This progression is not merely a matter of wording; it reflects the continuous evolution of Fosun's globalization capabilities. What began as establishing business presence later evolved into capability building, and today, we are truly integrating operations and investments on a global scale.

Regarding the insurance sector, our acquisition of Fosun Insurance Portugal in 2014 has evolved far beyond the initial "buyout". While continuing to deepen its presence in the local market, we have also empowered it to expand beyond Portugal into Europe, Latin America, and Africa. In 2025, Fosun Insurance Portugal delivered a profit attributable to owners of the parent of approximately EUR201 million, with international operations accounting for over 30% of its consolidated businesses. Building on years of development, the two domestic insurance companies have also reached a new stage of profitable and high‑quality growth. In 2025, Fosun United Health Insurance reported insurance revenue of RMB7.84 billion, representing a year-on-year increase of 50.1%, with net profit for the year reaching RMB139 million, marking five consecutive years of profitability. Pramerica Fosun Life Insurance achieved RMB13.28 billion in scale premium, representing a year-on-year increase of 41.6%, while net profit surged 492% year-on-year to RMB650 million. While continuing to develop our core insurance business, we also recognize that in the current landscape, a number of existing assets with long‑term value potential are ready to be revitalized through transformation, upgrading, and strong operational management. Some of these assets not only generate stable cash flows and provide a foundation for long‑term returns, but also have clearly defined risk boundaries, offering useful reference points for long‑term capital allocation, including by insurance institutions.

Regarding the consumer sector, Yuyuan has accelerated product innovation and channel optimization. Its catering brand, Songhelou, opened its first overseas branch in London, the United Kingdom, while jewelry brand, Laomiao, opened its first overseas store in Kuala Lumpur, Malaysia. FTG, with Club Med as its core, has firmly strengthened lean management. During the core six-day Chinese New Year holiday period, Club Med's five all-inclusive resorts in China recorded an average occupancy rate of 90%. During the nine-day Chinese New Year holiday period, Atlantis Sanya recorded business volume of over RMB124 million, representing a year-on-year increase of 20% and achieving its best Chinese New Year performance on record.

In the Intelligent Manufacturing segment, Hainan Mining, rooted in Hainan and expanding globally, focuses on the most upstream exploration, mining, processing and sales of strategic mineral resources. It has built a diversified global resource footprint spanning China, Southeast Asia, West Africa, and the Middle East, with mineral products covering various strategic mineral resources such as iron ore, lithium, oil, and natural gas. In 2025, supported by the steady advancement of overseas resource projects, the share of overseas assets rose to 46.04%.

More importantly, our globalization strategy has evolved from "acquiring globally" to the 3.0 era of "earning globally". Our products, brands, and services are now reaching customers around the world. The proportion of overseas revenue of Henlius' products such as HANQUYOU and HANSIZHUANG continues to rise. Our nationally recognized intangible cultural heritage event, the Yuyuan Lantern Festival, along with time‑honored Chinese brands such as Laomiao, Songhelou, and Nanxiang Steamed Buns Restaurant, and Shede baijiu are also gaining growing recognition among families in overseas markets. For Fosun, globalization is not a choice, it is inevitable. We have already proven that this path works, and we will go even further in the years ahead.

Staying true to our original aspiration and adhering to long-termism

Fosun has always stayed true to its original aspiration: to do the right things, the difficult things and the things that take time to develop.

We have always said that we must learn to move with the cycles while staying grounded in intrinsic value. Fluctuations in corporate value often stem from three overlapping cycles: the industry cycle, the capital market cycle, and the company's own cycle. The first two cycles are largely beyond our control. All we can do is to remain patient and wait them out. What we can change, however, is our own cycle. How well we manage our businesses and whether we have the right people in place are precisely the things we can improve through day‑to‑day operations and management. But patience takes time, and it also requires long-term capital. What kind of company does Fosun want to be? We need sufficient long-term capital to support our growth and the resilience to navigate through cycles. Just as importantly, we need the ability to continuously transform and strengthen our businesses.

This is why we must always remain committed to long-termism. Long-termism is not simply about "waiting". It is about continuously enhancing the Company's value in the process. As we wait for the industry cycle and capital markets cycle to turn, we must first manage our own cycle well. This is the key to Fosun's ability to navigate through cycles, and it is the long-termism we have upheld for over thirty years and will continue to uphold.

Doing good through business has always been part of our original aspiration. Over the past three decades, no matter the cycle, I have firmly believed that the value a company creates comes not only from its products, but also from the lives it touches and the social responsibilities it carries. Fosun Pharma has long worked to expand global access to artemisinin‑based medicines. In addition to improving drug quality through technology innovation, we have collaborated with many global charitable organizations to build local supply networks in Africa, ensuring that children in less developed regions can afford and access life-saving medicines. Bridging the "last mile" is never easy, but every additional bottle of medicine could mean one more child saved. Take HANSIZHUANG as another example, traditional chemotherapy for gastric cancer often brings severe side effects, causing many patients to abandon treatment. After 15 years of R&D, we brought HANSIZHUANG to market, ushering in a chemotherapy-free era in gastric cancer treatment. It not only allows patients to live longer, but also to live with dignity, and in some cases, even to offer hope for a cure. Our long-standing Rural Doctors Program addresses the reality that "minor illnesses often turn into serious illnesses" in remote areas. Operating in 78 key rural revitalization counties across 16 provinces, the Rural Doctors Program has supported 25,000 rural doctors, benefiting 3 million grassroots families across China's central and western regions. This is not a one‑off assistance effort, but a long‑term commitment to protecting the elderly and children who still live in rural areas and cannot easily travel to big cities.

Fosun has integrated ESG principles into every aspect of its development. We are actively promoting carbon neutrality and continuously investing in green energy, energy conservation and emission reduction, and eco-friendly materials. We are committed to compliant operations and we continue to strengthen transparency in our disclosures, so shareholders and the society can better understand Fosun. For us, an outstanding company is one that delivers commercial value while also taking responsibility for society and the environment.

To our shareholders and friends, "repairing the roof on a sunny day" requires both courage and resolve. Our core businesses remain solid, our liquidity position is robust, and our banking relationships remain stable. That is what gives us the confidence to move forward with this round of provisions. As we recently announced, our major shareholder and management team plan to increase their holdings in the shares of the Company and we will also proceed with a share buyback program. With our core businesses continuing to grow and our strategic plans firmly on track, we are confident in our ability to support a return of the share price to fair value and better protect the long-term interests of our shareholders. Our medium‑term financial goals are as follows: we strive to gradually restore annual profit to the RMB10 billion level; at the group level, we aim to generate RMB60 billion in cash returns, reduce total debt to below RMB60 billion, and strive to achieve an investment‑grade rating.

I would like to thank our shareholders and friends for your trust, understanding, and steadfast support over the years. Over the past more than thirty years, Fosun has come a long way and weathered many challenges. Looking back, none of it was in vain. We are grateful to this era for the opportunities it has given us, and we are equally grateful for the lessons we have paid for, which have made us more clear-eyed and more resolute.

For Fosun's future, we do not seek short-term gains; we seek to build a foundation for lasting success. We look forward to working side by side with all of you and, with prudent and pragmatic resolve and action, embracing a future in which Fosun renews itself through transformation and gathers strength for new growth.

Guo Guangchang

30 March 2026

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23:27
Fosun International: Total Revenue in 2025 Reaches RMB173.43 Billion, with Overseas Revenue Accounting for 54.7%, Aiming to Achieve"RMB10 Billion in Profit"

HONG KONG, March 30, 2026 /PRNewswire/ -- On 30 March, Fosun International (00656.HK) announced its results for the 12 months ended 31 December 2025. In 2025, Fosun's fundamentals remained solid, core industries such as pharmaceuticals and healthcare and insurance and finance demonstrated a good development trend, and the twin drivers of innovation and globalization delivered strong momentum.

During the Reporting Period, the Group's total revenue reached RMB173.43 billion, and adjusted industrial operation profit amounted to RMB4 billion. The four core subsidiaries generated RMB128.2 billion in revenue, accounting for 74% of the Group's total revenue. Among them, Fosun Pharma, a core subsidiary in the Health segment, achieved a net profit attributable to shareholders of the parent of RMB3.371 billion, representing a year-on-year increase of 21.69%; Fosun Insurance Portugal, a core subsidiary in the Wealth segment, reported a net profit attributable to owners of the parent of EUR201 million, up 15.8% year on year.

During the Reporting Period, the Group's investment in technology innovation reached RMB7.8 billion, and 16 indications of 7 innovative drugs were approved for marketing in China and overseas markets. In addition, nearly 40 innovative drug clinical trials were approved by regulatory authorities in China, the United States and Europe, while multiple core products entered key clinical phases, laying a solid pipeline foundation for subsequent commercial growth.

During the Reporting Period, the Group's overseas revenue reached RMB94.86 billion, accounting for 54.7% of total revenue, representing a year-on-year increase of 5.4 percentage points. For innovative drugs, total upfront payments from licensing-out and co-development for the year exceeded USD260 million, with total potential milestone payments exceeding USD4 billion. Club Med once again achieved record-high performance, while insurance companies in China and overseas delivered broad-based growth.

Fosun has continued to advance its strategy of "streamlining operations and strengthening the business, focusing on core businesses". During the Reporting Period, pursuant to the principle of prudence, Fosun made non-cash impairment provisions and value revaluations on certain real estate projects with impairment indicators and goodwill and intangible assets of certain non-core business segments, resulting in a book loss of RMB23.4 billion for the year, of which real estate-related impairment accounted for approximately 55%, while impairment of non-core assets accounted for approximately 45%. These provisions do not affect the Company's overall operations and cash flow.

In his letter to shareholders, Guo Guangchang, Chairman of Fosun International, stated: "Some of the projects we invested in years ago are now indeed valued differently under current market conditions from what we expected at the time of investment. Accordingly, the Board has prudently chosen to complete this asset impairment, allowing Fosun to better concentrate its resources and efforts on high-growth core sectors. As the global economy presents opportunities amid fluctuations and China's innovation industry gains momentum, deepening our strategic focus now allows us not only to optimize our asset structure, but also to seize industry opportunities, positioning Fosun as a leaner, healthier, and more sustainable company."

At the same time, Fosun has maintained a healthy financial position, with ample cash reserves, a solid net asset base, and positive net cash inflow from operating activities. As at the end of the Reporting Period, total debt to total capital ratio was 57%; in addition to cash, bank balances and term deposits of RMB61.1 billion, unutilized banking facilities amounted to RMB144.6 billion. A healthy debt ratio and ample funds not only strengthen the Company's risk resilience, but also enhance its capacity to seize opportunities. International rating agency S&P has affirmed the outlook for Fosun International's credit rating as "Stable".

"It is precisely this strong foundation, together with the continued support of our partners, that gives us the confidence and determination to 'repair the roof while the sun is shining' — to shed burdens at this stage and pursue predictable, sustainable growth for the future. We must strengthen our core businesses with greater focus and depth. This is the path for Fosun to move more steadily and go further in the next phase," said Guo Guangchang.

Fosun also announced its medium-term financial targets: to strive to gradually restore annual profit to around RMB10 billion; to target the recovery of RMB60 billion in cash at the Group level, reduce total Group-level debt to below RMB60 billion, and work to achieve an "investment-grade" rating.

In terms of further enhancing shareholder returns, in addition to share purchases by the controlling shareholder and management, as well as the Company's continued share buybacks, Fosun announced that it plans to increase its target dividend payout ratio for the 2026 financial year from the current 20% to 35%, and is committed to further raising the payout ratio over time. Based on the Company's accumulated distributable profits, dividends for the 2026 financial year are expected to be no less than HKD1.5 billion.

"For the future, Fosun will not pursue short-term gains; instead, we will build a solid foundation for enduring growth," said Guo Guangchang.

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